Reaction Details Report a problem with these data
Target
Orphan methyltransferase M.SssI
Ligand
BDBM50389482
Substrate
n/a
Meas. Tech.
ChEMBL_832312 (CHEMBL2066850)
Ki
70000±n/a nM
Citation
 Plitta, B; Adamska, E; Giel-Pietraszuk, M; Fedoruk-Wyszomirska, A; Naskret-Barciszewska, M; Markiewicz, WT; Barciszewski, J New cytosine derivatives as inhibitors of DNA methylation. Eur J Med Chem 55:243-54 (2012) [PubMed]  Article 
Target
Name:
Orphan methyltransferase M.SssI
Synonyms:
CpG DNA methylase | M.SssI methyltransferase | MTSI_SPISQ | mssSI | sssIM
Type:
Protein
Mol. Mass.:
44323.75
Organism:
Spiroplasma monobiae strain MQ-1
Description:
P15840
Residue:
386
Sequence:
MSKVENKTKKLRVFEAFAGIGAQRKALEKVRKDEYEIVGLAEWYVPAIVMYQAIHNNFHTKLEYKSVSREEMIDYLENKTLSWNSKNPVSNGYWKRKKDDELKIIYNAIKLSEKEGNIFDIRDLYKRTLKNIDLLTYSFPCQDLSQQGIQKGMKRGSGTRSGLLWEIERALDSTEKNDLPKYLLMENVGALLHKKNEEELNQWKQKLESLGYQNSIEVLNAADFGSSQARRRVFMISTLNEFVELPKGDKKPKSIKKVLNKIVSEKDILNNLLKYNLTEFKKTKSNINKASLIGYSKFNSEGYVYDPEFTGPTLTASGANSRIKIKDGSNIRKMNSDETFLYIGFDSQDGKRVNEIEFLTENQKIFVCGNSISVEVLEAIIDKIGG
  
Inhibitor
Name:
BDBM50389482
Synonyms:
CHEMBL1699292
Type:
Small organic molecule
Emp. Form.:
C9H9N3O2
Mol. Mass.:
191.1867
SMILES:
O=c1nccc(NCc2ccco2)[nH]1
Structure:
Search PDB for entries with ligand similarity: