Reaction Details Report a problem with these data
Target
Ephrin type-A receptor 3
Ligand
BDBM50345740
Substrate
n/a
Meas. Tech.
ChEMBL_834207 (CHEMBL2072947)
IC50
3700±n/a nM
Citation
 Johnson, SM; Murphy, RC; Geiger, JA; DeRocher, AE; Zhang, Z; Ojo, KK; Larson, ET; Perera, BG; Dale, EJ; He, P; Reid, MC; Fox, AM; Mueller, NR; Merritt, EA; Fan, E; Parsons, M; Van Voorhis, WC; Maly, DJ Development of Toxoplasma gondii calcium-dependent protein kinase 1 (TgCDPK1) inhibitors with potent anti-toxoplasma activity. J Med Chem 55:2416-26 (2012) [PubMed]  Article 
Target
Name:
Ephrin type-A receptor 3
Synonyms:
EPHA3 | EPHA3_HUMAN | ETK | ETK1 | Ephrin receptor | Ephrin type-A receptor 3 | Ephrin type-A receptor 3 (EPHA3) | HEK | TYRO4
Type:
Protein
Mol. Mass.:
110131.95
Organism:
Homo sapiens (Human)
Description:
P29320
Residue:
983
Sequence:
MDCQLSILLLLSCSVLDSFGELIPQPSNEVNLLDSKTIQGELGWISYPSHGWEEISGVDEHYTPIRTYQVCNVMDHSQNNWLRTNWVPRNSAQKIYVELKFTLRDCNSIPLVLGTCKETFNLYYMESDDDHGVKFREHQFTKIDTIAADESFTQMDLGDRILKLNTEIREVGPVNKKGFYLAFQDVGACVALVSVRVYFKKCPFTVKNLAMFPDTVPMDSQSLVEVRGSCVNNSKEEDPPRMYCSTEGEWLVPIGKCSCNAGYEERGFMCQACRPGFYKALDGNMKCAKCPPHSSTQEDGSMNCRCENNYFRADKDPPSMACTRPPSSPRNVISNINETSVILDWSWPLDTGGRKDVTFNIICKKCGWNIKQCEPCSPNVRFLPRQFGLTNTTVTVTDLLAHTNYTFEIDAVNGVSELSSPPRQFAAVSITTNQAAPSPVLTIKKDRTSRNSISLSWQEPEHPNGIILDYEVKYYEKQEQETSYTILRARGTNVTISSLKPDTIYVFQIRARTAAGYGTNSRKFEFETSPDSFSISGESSQVVMIAISAAVAIILLTVVIYVLIGRFCGYKSKHGADEKRLHFGNGHLKLPGLRTYVDPHTYEDPTQAVHEFAKELDATNISIDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIRLEGVVTKSKPVMIVTEYMENGSLDSFLRKHDAQFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTSPEAIAYRKFTSASDVWSYGIVLWEVMSYGERPYWEMSNQDVIKAVDEGYRLPPPMDCPAALYQLMLDCWQKDRNNRPKFEQIVSILDKLIRNPGSLKIITSAAARPSNLLLDQSNVDITTFRTTGDWLNGVWTAHCKEIFTGVEYSSCDTIAKISTDDMKKVGVTVVGPQKKIISSIKALETQSKNGPVPV
  
Inhibitor
Name:
BDBM50345740
Synonyms:
3-(6-ethoxynaphthalen-2-yl)-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine | CHEMBL1785021 | CHEMBL2070048 | US10544104, Compound 7r | US11247972, Compound 7r | US9765037, Compound 7r
Type:
Small organic molecule
Emp. Form.:
C20H21N5O
Mol. Mass.:
347.4136
SMILES:
CCOc1ccc2cc(ccc2c1)-c1nn(C(C)C)c2ncnc(N)c12
Structure:
Search PDB for entries with ligand similarity: