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Target
Adenosine receptor A1
Ligand
BDBM50389921
Substrate
n/a
Meas. Tech.
ChEMBL_834861 (CHEMBL2073178)
Ki
1299±n/a nM
Citation
 Baraldi, PG; Saponaro, G; Romagnoli, R; Aghazadeh Tabrizi, M; Baraldi, S; Moorman, AR; Cosconati, S; Di Maro, S; Marinelli, L; Gessi, S; Merighi, S; Varani, K; Borea, PA; Preti, D Water-soluble pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines as human A3 adenosine receptor antagonists. J Med Chem 55:5380-90 (2012) [PubMed]  Article 
Target
Name:
Adenosine receptor A1
Synonyms:
A1 adenosine receptor (hA1) | A1AR | AA1R_HUMAN | ADENOSINE A1 | ADORA1 | Adenosine A1 receptor (A1AR) | Adenosine A1-receptor | Adenosine receptor A1 (A1) | Adenosine receptor A1 (hA1) | Adenosine transporter (AdT)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36520.92
Organism:
Homo sapiens (Human)
Description:
P30542
Residue:
326
Sequence:
MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVTPRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFLKIWNDHFRCQPAPPIDEDLPEERPDD
  
Inhibitor
Name:
BDBM50389921
Synonyms:
CHEMBL2071050
Type:
Small organic molecule
Emp. Form.:
C23H23N11O3
Mol. Mass.:
501.5006
SMILES:
Cn1cc2c(n1)nc(NC(=O)NC1CCN(CC1)C(=O)Nc1ccncc1)n1nc(nc21)-c1ccco1
Structure:
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