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Target
Dipeptidyl peptidase 4
Ligand
BDBM50390183
Substrate
n/a
Meas. Tech.
ChEMBL_834623 (CHEMBL2072423)
IC50
94.4±n/a nM
Citation
 Kim, HJ; Kwak, WY; Min, JP; Sung, SY; Kim, HD; Kim, MK; Kim, HS; Park, KJ; Son, MH; Kim, SH; Lee, BJ Dipeptidyl peptidase-4 inhibitor withß-amino amide scaffold: synthesis, SAR and biological evaluation. Bioorg Med Chem Lett 22:5545-9 (2012) [PubMed]  Article 
Target
Name:
Dipeptidyl peptidase 4
Synonyms:
Cd26 | DPP4_MOUSE | Dipeptidyl peptidase IV | Dpp4
Type:
PROTEIN
Mol. Mass.:
87433.73
Organism:
Mus musculus
Description:
ChEMBL_1335112
Residue:
760
Sequence:
MKTPWKVLLGLLGVAALVTIITVPIVLLSKDEAAADSRRTYSLADYLKSTFRVKSYSLWWVSDFEYLYKQENNILLLNAEHGNSSIFLENSTFESFGYHSVSPDRLFVLLEYNYVKQWRHSYTASYNIYDVNKRQLITEEKIPNNTQWITWSPEGHKLAYVWKNDIYVKVEPHLPSHRITSTGEENVIYNGITDWVYEEEVFGAYSALWWSPNNTFLAYAQFNDTGVPLIEYSFYSDESLQYPKTVWIPYPKAGAVNPTVKFFIVNIDSLSSSSSAAPIQIPAPASVARGDHYLCDVVWATEERISLQWLRRIQNYSVMAICDYDKINLTWNCPSEQQHVEMSTTGWVGRFRPAEPHFTSDGSSFYKIISDKDGYKHICHFPKDKKDCTFITKGAWEVISIEALTSDYLYYISNQYKEMPGGRNLYKIQLTDHTNVKCLSCDLNPERCQYYAVSFSKEAKYYQLGCWGPGLPLYTLHRSTDHKELRVLEDNSALDRMLQDVQMPSKKLDFIVLNETRFWYQMILPPHFDKSKKYPLLLDVYAGPCSQKADASFRLNWATYLASTENIIVASFDGRGSGYQGDKIMHAINRRLGTLEVEDQIEAARQFVKMGFVDSKRVAIWGWSYGGYVTSMVLGSGSGVFKCGIAVAPVSRWEYYDSVYTERYMGLPIPEDNLDHYRNSTVMSRAEHFKQVEYLLIHGTADDNVHFQQSAQISKALVDAGVDFQAMWYTDEDHGIASSTAHQHIYSHMSHFLQQCFSLH
  
Inhibitor
Name:
BDBM50390183
Synonyms:
CHEMBL2069830
Type:
Small organic molecule
Emp. Form.:
C20H20F5N3O
Mol. Mass.:
413.3843
SMILES:
N[C@@H](CC(=O)N1CCN(CC1)c1ccc(F)cc1F)Cc1cc(F)c(F)cc1F |r|
Structure:
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