Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50125096
Substrate
n/a
Meas. Tech.
ChEMBL_834665 (CHEMBL2072551)
Ki
5.81±n/a nM
Citation
 Moussa, IA; Banister, SD; Manoli, M; Doddareddy, MR; Cui, J; Mach, RH; Kassiou, M Exploration of ring size in a series of cyclic vicinal diamines withs1 receptor affinity. Bioorg Med Chem Lett 22:5493-7 (2012) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25124.85
Organism:
Homo sapiens (Human)
Description:
Q99720
Residue:
223
Sequence:
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50125096
Synonyms:
1,4-Dibenzyl-piperazine | 1,4-Dibenzyl-piperazine, 9 | 1,4-Dibenzylpiperazine | CHEMBL162522 | US10166229, Example 00032
Type:
Small organic molecule
Emp. Form.:
C18H22N2
Mol. Mass.:
266.3807
SMILES:
C(N1CCN(Cc2ccccc2)CC1)c1ccccc1
Structure:
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