Reaction Details Report a problem with these data
Target
S-methyl-5'-thioadenosine phosphorylase
Ligand
BDBM50390241
Substrate
n/a
Meas. Tech.
ChEMBL_834947 (CHEMBL2073357)
Ki
12±n/a nM
Citation
 Clinch, K; Evans, GB; Fröhlich, RF; Gulab, SA; Gutierrez, JA; Mason, JM; Schramm, VL; Tyler, PC; Woolhouse, AD Transition state analogue inhibitors of human methylthioadenosine phosphorylase and bacterial methylthioadenosine/S-adenosylhomocysteine nucleosidase incorporating acyclic ribooxacarbenium ion mimics. Bioorg Med Chem 20:5181-7 (2012) [PubMed]  Article 
Target
Name:
S-methyl-5'-thioadenosine phosphorylase
Synonyms:
5'-Methylthioadenosine phosphorylase (MTAP) | MSAP | MTA phosphorylase | MTAP | MTAP_HUMAN | MTAPase | Methylthioadenosine Phosphorylase (MTAP) | S-methyl-5 -thioadenosine phosphorylase
Type:
Enzyme
Mol. Mass.:
31239.23
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
283
Sequence:
MASGTTTTAVKIGIIGGTGLDDPEILEGRTEKYVDTPFGKPSDALILGKIKNVDCVLLARHGRQHTIMPSKVNYQANIWALKEEGCTHVIVTTACGSLREEIQPGDIVIIDQFIDRTTMRPQSFYDGSHSCARGVCHIPMAEPFCPKTREVLIETAKKLGLRCHSKGTMVTIEGPRFSSRAESFMFRTWGADVINMTTVPEVVLAKEAGICYASIAMATDYDCWKEHEEAVSVDRVLKTLKENANKAKSLLLTTIPQIGSTEWSETLHNLKNMAQFSVLLPRH
  
Inhibitor
Name:
BDBM50390241
Synonyms:
CHEMBL2070307
Type:
Small organic molecule
Emp. Form.:
C11H17N5OS
Mol. Mass.:
267.351
SMILES:
CSCC(CO)NCc1c[nH]c2c(N)ncnc12
Structure:
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