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Target
Inhibitor of nuclear factor kappa-B kinase subunit beta
Ligand
BDBM50390275
Substrate
n/a
Meas. Tech.
ChEMBL_835035 (CHEMBL2073527)
IC50
7000±n/a nM
Citation
 Song, H; Lee, YS; Roh, EJ; Seo, JH; Oh, KS; Lee, BH; Han, H; Shin, KJ Discovery of potent and selective rhodanine type IKKß inhibitors by hit-to-lead strategy. Bioorg Med Chem Lett 22:5668-74 (2012) [PubMed]  Article 
Target
Name:
Inhibitor of nuclear factor kappa-B kinase subunit beta
Synonyms:
IKKB_MOUSE | Ikbkb | Ikkb
Type:
PROTEIN
Mol. Mass.:
86687.79
Organism:
Mus musculus
Description:
ChEMBL_835035
Residue:
757
Sequence:
MSWSPSLPTQTCGAWEMKERLGTGGFGNVIRWHNQATGEQIAIKQCRQELSPKNRNRWCLEIQIMRRLNHPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRRYLNQFENCCGLREGAVLTLLSDIASALRYLHENRIIHRDLKPENIVLQQGEKRLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSEVDIVVSEDLNGAVKFSSSLPFPNNLNSVLAERLEKWLQLMLMWHPRQRGTDPQYGPNGCFRALDDILNLKLVHVLNMVTGTVHTYPVTEDESLQSLKTRIQENTGILETDQELLQKAGLVLLPDKPATQCISDSKTNEGLTLDMDLVFLLDNSKINYETQITPRPPPESVSCILQEPKRNLSFFQLRKVWGQVWHSIQTLKEDCNRLQQGQRAAMMSLLRNNSCLSKMKNAMASTAQQLKAKLDFFKTSIQIDLEKYKEQTEFGITSDKLLLAWREMEQAVEQCGRENDVKHLVERMMALQTDIVDLQRSPMGRKQGGTLDDLEEQARELYRKLREKPRDQRTEGDSQEMVRLLLQAIQSFEKKVRVIYTQLSKTVVCKQKALELLPKVEEVVSLMNEDERTVVRLQEKRQKELWNLLKIACSKVRGPVSGSPDSMNVSRLSHPGQLMSQPSSACDSLPESDKKSEELVAEAHALCSRLESALQDTVKEQDRSFTTLDWSWLQMEDEERCSLEQACD
  
Inhibitor
Name:
BDBM50390275
Synonyms:
CHEMBL2070423
Type:
Small organic molecule
Emp. Form.:
C29H29N3O4S2
Mol. Mass.:
547.688
SMILES:
CCN(CC)CCOc1ccc(cc1)N1C(=S)S\C(=C/c2ccc(Oc3cccc(c3)C(N)=O)cc2)C1=O
Structure:
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