Reaction Details Report a problem with these data
Target
Ileal sodium/bile acid cotransporter
Ligand
BDBM50390996
Substrate
n/a
Meas. Tech.
ChEMBL_836829 (CHEMBL2075354)
Ki
10000±n/a nM
Citation
 Hallén, S; Björquist, A; Ostlund-Lindqvist, AM; Sachs, G Identification of a region of the ileal-type sodium/bile acid cotransporter interacting with a competitive bile acid transport inhibitor. Biochemistry 41:14916-14924 (2002) [PubMed]  Article 
Target
Name:
Ileal sodium/bile acid cotransporter
Synonyms:
ASBT | Apical sodium-dependent bile acid transporter | IBAT | ISBT | Ileal Na(+)/bile acid cotransporter | Ileal bile acid transporter | Ileal bile acid transporter/bile acid cotransporter | Ileal sodium-dependent bile acid transporter | NTCP2 | NTCP2_HUMAN | SLC10A2
Type:
Enzyme
Mol. Mass.:
37714.89
Organism:
Homo sapiens (Human)
Description:
SLC10A2
Residue:
348
Sequence:
MNDPNSCVDNATVCSGASCVVPESNFNNILSVVLSTVLTILLALVMFSMGCNVEIKKFLGHIKRPWGICVGFLCQFGIMPLTGFILSVAFDILPLQAVVVLIIGCCPGGTASNILAYWVDGDMDLSVSMTTCSTLLALGMMPLCLLIYTKMWVDSGSIVIPYDNIGTSLVSLVVPVSIGMFVNHKWPQKAKIILKIGSIAGAILIVLIAVVGGILYQSAWIIAPKLWIIGTIFPVAGYSLGFLLARIAGLPWYRCRTVAFETGMQNTQLCSTIVQLSFTPEELNVVFTFPLIYSIFQLAFAAIFLGFYVAYKKCHGKNKAEIPESKENGTEPESSFYKANGGFQPDEK
  
Inhibitor
Name:
BDBM50390996
Synonyms:
CHEMBL2074988
Type:
Small organic molecule
Emp. Form.:
C21H27NO2S
Mol. Mass.:
357.51
SMILES:
CCCC[C@]1(CC)CS(=O)(=O)c2ccccc2[C@H](N1)c1ccccc1 |r|
Structure:
Search PDB for entries with ligand similarity: