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Target
Indoleamine 2,3-dioxygenase 1
Ligand
BDBM17452
Substrate
n/a
Meas. Tech.
ChEMBL_847931 (CHEMBL2150231)
IC50
>100000±n/a nM
Citation
 Röhrig, UF; Majjigapu, SR; Grosdidier, A; Bron, S; Stroobant, V; Pilotte, L; Colau, D; Vogel, P; Van den Eynde, BJ; Zoete, V; Michielin, O Rational design of 4-aryl-1,2,3-triazoles for indoleamine 2,3-dioxygenase 1 inhibition. J Med Chem 55:5270-90 (2012) [PubMed]  Article 
Target
Name:
Indoleamine 2,3-dioxygenase 1
Synonyms:
I23O1_HUMAN | IDO | IDO-1 | IDO1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine 2,3-dioxygenase | Indoleamine-pyrrole 2,3-dioxygenase
Type:
Enzyme
Mol. Mass.:
45330.80
Organism:
Homo sapiens (Human)
Description:
P14902
Residue:
403
Sequence:
MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQQPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
  
Inhibitor
Name:
BDBM17452
Synonyms:
1,2,3-triazole analogue, 8 | 5-(2-methylphenyl)-1H-1,2,3-triazole
Type:
Small organic molecule
Emp. Form.:
C9H9N3
Mol. Mass.:
159.1879
SMILES:
Cc1ccccc1-c1c[nH]nn1
Structure:
Search PDB for entries with ligand similarity: