Reaction Details Report a problem with these data
Target
Enoyl-[acyl-carrier-protein] reductase [NADH]
Ligand
BDBM50392117
Substrate
n/a
Meas. Tech.
ChEMBL_851462 (CHEMBL2156468)
Ki
360±n/a nM
Citation
 Mehboob, S; Hevener, KE; Truong, K; Boci, T; Santarsiero, BD; Johnson, ME Structural and enzymatic analyses reveal the binding mode of a novel series of Francisella tularensis enoyl reductase (FabI) inhibitors. J Med Chem 55:5933-41 (2012) [PubMed]  Article 
Target
Name:
Enoyl-[acyl-carrier-protein] reductase [NADH]
Synonyms:
fabI
Type:
PROTEIN
Mol. Mass.:
27804.42
Organism:
Francisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4)
Description:
Q5NGQ3
Residue:
260
Sequence:
MGFLAGKKILITGLLSNKSIAYGIAKAMHREGAELAFTYVGQFKDRVEKLCAEFNPAAVLPCDVISDQEIKDLFVELGKVWDGLDAIVHSIAFAPRDQLEGNFIDCVTREGFSIAHDISAYSFAALAKEGRSMMKNRNASMVALTYIGAEKAMPSYNTMGVAKASLEATVRYTALALGEDGIKVNAVSAGPIKTLAASGISNFKKMLDYNAMVSPLKKNVDIMEVGNTVAFLCSDMATGITGEVVHVDAGYHCVSMGNVL
  
Inhibitor
Name:
BDBM50392117
Synonyms:
CHEMBL1945507
Type:
Small organic molecule
Emp. Form.:
C16H14Cl2N2
Mol. Mass.:
305.202
SMILES:
Cc1cc2ncn(Cc3ccc(Cl)c(Cl)c3)c2cc1C
Structure:
Search PDB for entries with ligand similarity: