Reaction Details Report a problem with these data
Target
Hydroxysteroid 11-beta dehydrogenase 1
Ligand
BDBM50392216
Substrate
n/a
Meas. Tech.
ChEMBL_850498 (CHEMBL2157619)
IC50
3770±n/a nM
Citation
Scott, JS; Bowker, SS; Deschoolmeester, J; Gerhardt, S; Hargreaves, D; Kilgour, E; Lloyd, A; Mayers, RM; McCoull, W; Newcombe, NJ; Ogg, D; Packer, MJ; Rees, A; Revill, J; Schofield, P; Selmi, N; Swales, JG; Whittamore, PR Discovery of a potent, selective, and orally bioavailable acidic 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD1) inhibitor: discovery of 2-[(3S)-1-[5-(cyclohexylcarbamoyl)-6-propylsulfanylpyridin-2-yl]-3-piperidyl]acetic acid (AZD4017). J Med Chem 55:5951-64 (2012) [PubMed] Article
More Info.:
Target
Name:
Hydroxysteroid 11-beta dehydrogenase 1
Synonyms:
11-beta-hydroxysteroid dehydrogenase type 1
Type:
PROTEIN
Mol. Mass.:
32020.70
Organism:
Canis familiaris
Description:
ChEMBL_850498
Residue:
293
Sequence:
MAFKKKYLPPLLGFFLAYYYYSANEEFRPEMLQGKKVIVTGASKGIGEQMAYHLAKMGAHVVVTARSKETLKKVVSHCLELGAASAHYIPGTMEDMTFAEQFVAKAGKLMGGLDMLILNHITNTSMNLFSGDIHLVRRSMEVNFLSYVVLSAAALPMLKQSNGSIVVVSSKAGKMSSPLVAPYSASKFALDGFFSSVRMEHSVTKVNVSITLCILGLINTDTAMKAVSGILSTVGASSKEECALEIIKGGALRQEEVYYDNSVWTAFLLGNPGRKILEFLSLRSYKLDKFINN