Reaction Details Report a problem with these data
Target
Asparagine synthetase [glutamine-hydrolyzing]
Ligand
BDBM50392271
Substrate
n/a
Meas. Tech.
ChEMBL_851317 (CHEMBL2156024)
Ki
4500±n/a nM
Citation
Ikeuchi, H; Ahn, YM; Otokawa, T; Watanabe, B; Hegazy, L; Hiratake, J; Richards, NG A sulfoximine-based inhibitor of human asparagine synthetase kills L-asparaginase-resistant leukemia cells. Bioorg Med Chem 20:5915-27 (2012) [PubMed] Article
More Info.:
Target
Name:
Asparagine synthetase [glutamine-hydrolyzing]
Synonyms:
ASNS | ASNS_HUMAN | Asparagine synthetase | TS11
Type:
PROTEIN
Mol. Mass.:
64373.20
Organism:
Homo sapiens (Human)
Description:
ChEMBL_851327
Residue:
561
Sequence:
MCGIWALFGSDDCLSVQCLSAMKIAHRGPDAFRFENVNGYTNCCFGFHRLAVVDPLFGMQPIRVKKYPYLWLCYNGEIYNHKKMQQHFEFEYQTKVDGEIILHLYDKGGIEQTICMLDGVFAFVLLDTANKKVFLGRDTYGVRPLFKAMTEDGFLAVCSEAKGLVTLKHSATPFLKVEPFLPGHYEVLDLKPNGKVASVEMVKYHHCRDVPLHALYDNVEKLFPGFEIETVKNNLRILFNNAVKKRLMTDRRIGCLLSGGLDSSLVAATLLKQLKEAQVQYPLQTFAIGMEDSPDLLAARKVADHIGSEHYEVLFNSEEGIQALDEVIFSLETYDITTVRASVGMYLISKYIRKNTDSVVIFSGEGSDELTQGYIYFHKAPSPEKAEEESERLLRELYLFDVLRADRTTAAHGLELRVPFLDHRFSSYYLSLPPEMRIPKNGIEKHLLRETFEDSNLIPKEILWRPKEAFSDGITSVKNSWFKILQEYVEHQVDDAMMANAAQKFPFNTPKTKEGYYYRQVFERHYPGRADWLSHYWMPKWINATDPSARTLTHYKSAVKA