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TargetCholesteryl ester transfer protein
LigandBDBM50392530
Substrate/Competitorn/a
Meas. Tech.ChEMBL_852276
IC50 3±n/a nM
Citation Miller, MMLiu, YJiang, JJohnson, JAKamau, MNirschl, DSWang, YHarikrishnan, LTaylor, DSChen, AYYin, XSeethala, RPeterson, TLZvyaga, TZhang, JHuang, CSWexler, RRPoss, MALawrence, RMAdam, LPSalvati, ME Identification of a potent and metabolically stable series of fluorinated diphenylpyridylethanamine-based cholesteryl ester transfer protein inhibitors. Bioorg Med Chem Lett22:6503-8 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cholesteryl ester transfer protein
Name:Cholesteryl ester transfer protein
Synonyms:Cholesteryl ester transfer protein (CETP) | Lipid transfer protein I
Type:Enzyme
Mol. Mass.:54751.53
Organism:Homo sapiens (Human)
Description:P11597
Residue:493
Sequence:
MLAATVLTLALLGNAHACSKGTSHEAGIVCRITKPALLVLNHETAKVIQTAFQRASYPDI
TGEKAMMLLGQVKYGLHNIQISHLSIASSQVELVEAKSIDVSIQNVSVVFKGTLKYGYTT
AWWLGIDQSIDFEIDSAIDLQINTQLTCDSGRVRTDAPDCYLSFHKLLLHLQGEREPGWI
KQLFTNFISFTLKLVLKGQICKEINVISNIMADFVQTRAASILSDGDIGVDISLTGDPVI
TASYLESHHKGHFIYKNVSEDLPLPTFSPTLLGDSRMLYFWFSERVFHSLAKVAFQDGRL
MLSLMGDEFKAVLETWGFNTNQEIFQEVVGGFPSQAQVTVHCLKMPKISCQNKGVVVNSS
VMVKFLFPRPDQQHSVAYTFEEDIVTTVQASYSKKKLFLSLLDFQITPKTVSNLTESSSE
SVQSFLQSMITAVGIPEVMSRLEVVFTALMNSKGVSLFDIINPEIITRDGFLLLQMDFGF
PEHLLVDFLQSLS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50392530
n/a
NameBDBM50392530
Synonyms:CHEMBL2152183
TypeSmall organic molecule
Emp. Form.C24H18ClF8N3O2
Mol. Mass.567.859
SMILESFC(F)C(F)(F)Oc1cc(F)cc(c1)[C@](Cc1ccccc1)(NC(=O)NCC(F)(F)F)c1ccc(Cl)cn1 |r|
Structure
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