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Target11-beta-hydroxysteroid dehydrogenase 1
LigandBDBM50392924
Substrate/Competitorn/a
Meas. Tech.ChEMBL_853422
IC50 0.1±n/a nM
Citation Yu, JLiu, HXia, GLiu, LXu, ZChen, QMa, CSun, XXu, JLi, HLi, PShi, YXiong, BLiu, XShen, J Discovery of 2-Alkyl-1-arylsulfonylprolinamides as 11-Hydroxysteroid Dehydrogenase Type 1 Inhibitors. ACS Med Chem Lett3:793-798 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
11-beta-hydroxysteroid dehydrogenase 1
Name:11-beta-hydroxysteroid dehydrogenase 1
Synonyms:11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1)
Type:Enzyme
Mol. Mass.:32409.16
Organism:Homo sapiens (Human)
Description:P28845
Residue:292
Sequence:
MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAH
VVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNH
ITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMV
AAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEE
CALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLYSTSYNMDRFINK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50392924
NameBDBM50392924
Synonyms:CHEMBL2152223
TypeSmall organic molecule
Emp. Form.C23H31ClN2O4S
Mol. Mass.467.021
SMILESCc1c(Cl)cccc1S(=O)(=O)N1CCC[C@]1(C)C(=O)N[C@H]1C2CC3CC1C[C@](O)(C3)C2 |r,wU:15.17,20.21,wD:15.18,27.30,TLB:19:20:30.26.27:24.23.22,19:20:22:30.27.29,28:27:20.25.24:22,THB:26:25:22:30.27.29,26:27:20.25.24:22,29:27:20:24.23.22,29:23:20:30.26.27,28:27:20:24.23.22,(11.34,-28.78,;11.34,-27.24,;10,-26.47,;8.67,-27.24,;10.01,-24.93,;11.34,-24.16,;12.67,-24.92,;12.68,-26.47,;14.01,-27.24,;14.77,-28.57,;13.24,-28.56,;15.34,-26.47,;15.5,-24.92,;17.01,-24.6,;17.78,-25.94,;16.74,-27.08,;17.83,-28.17,;16.35,-28.57,;15.24,-29.65,;17.43,-29.66,;18.92,-29.26,;20.12,-27.98,;20.11,-26.5,;21.46,-26.02,;20.42,-27.25,;20.42,-28.84,;21.83,-29.4,;22.84,-28.13,;24.38,-28.07,;22.85,-26.6,;21.45,-28.47,)|
Structure
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