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Target
Bromodomain-containing protein 2
Ligand
BDBM50365264
Substrate
n/a
Meas. Tech.
ChEMBL_852807 (CHEMBL2156114)
Kd
54±n/a nM
Citation
 Chung, CW; Coste, H; White, JH; Mirguet, O; Wilde, J; Gosmini, RL; Delves, C; Magny, SM; Woodward, R; Hughes, SA; Boursier, EV; Flynn, H; Bouillot, AM; Bamborough, P; Brusq, JM; Gellibert, FJ; Jones, EJ; Riou, AM; Homes, P; Martin, SL; Uings, IJ; Toum, J; Clement, CA; Boullay, AB; Grimley, RL; Blandel, FM; Prinjha, RK; Lee, K; Kirilovsky, J; Nicodeme, E Discovery and characterization of small molecule inhibitors of the BET family bromodomains. J Med Chem 54:3827-38 (2011) [PubMed]  Article 
Target
Name:
Bromodomain-containing protein 2
Synonyms:
BRD2 | BRD2_HUMAN | Bromodomain and extra-terminal motif (BET) | Bromodomain-containing protein 2 | Bromodomain-containing protein 2 (BRD2) | KIAA9001 | RING3
Type:
Protein
Mol. Mass.:
88085.95
Organism:
Homo sapiens (Human)
Description:
P25440
Residue:
801
Sequence:
MLQNVTPHNKLPGEGNAGLLGLGPEAAAPGKRIRKPSLLYEGFESPTMASVPALQLTPANPPPPEVSNPKKPGRVTNQLQYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQPMDMGTIKRRLENNYYWAASECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIFLQKVASMPQEEQELVVTIPKNSHKKGAKLAALQGSVTSAHQVPAVSSVSHTALYTPPPEIPTTVLNIPHPSVISSPLLKSLHSAGPPLLAVTAAPPAQPLAKKKGVKRKADTTTPTPTAILAPGSPASPPGSLEPKAARLPPMRRESGRPIKPPRKDLPDSQQQHQSSKKGKLSEQLKHCNGILKELLSKKHAAYAWPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCYKYNPPDHDVVAMARKLQDVFEFRYAKMPDEPLEPGPLPVSTAMPPGLAKSSSESSSEESSSESSSEEEEEEDEEDEEEEESESSDSEEERAHRLAELQEQLRAVHEQLAALSQGPISKPKRKREKKEKKKKRKAEKHRGRAGADEDDKGPRAPRPPQPKKSKKASGSGGGSAALGPSGFGPSGGSGTKLPKKATKTAPPALPTGYDSEEEEESRPMSYDEKRQLSLDINKLPGEKLGRVVHIIQAREPSLRDSNPEEIEIDFETLKPSTLRELERYVLSCLRKKPRKPYTIKKPVGKTKEELALEKKRELEKRLQDVSGQLNSTKKPPKKANEKTESSSAQQVAVSRLSASSSSSDSSSSSSSSSSSDTSDSDSG
  
Inhibitor
Name:
BDBM50365264
Synonyms:
CHEMBL1738926
Type:
Small organic molecule
Emp. Form.:
C25H21N5O2
Mol. Mass.:
423.4665
SMILES:
Cc1nnc2[C@H](NC(=O)OCc3ccccc3)N=C(c3ccccc3)c3ccccc3-n12 |r,t:18|
Structure:
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