Reaction Details Report a problem with these data
Target
Succinate receptor 1
Ligand
BDBM50393142
Substrate
n/a
Meas. Tech.
ChEMBL_852820 (CHEMBL2156127)
IC50
90±n/a nM
Citation
 Bhuniya, D; Umrani, D; Dave, B; Salunke, D; Kukreja, G; Gundu, J; Naykodi, M; Shaikh, NS; Shitole, P; Kurhade, S; De, S; Majumdar, S; Reddy, SB; Tambe, S; Shejul, Y; Chugh, A; Palle, VP; Mookhtiar, KA; Cully, D; Vacca, J; Chakravarty, PK; Nargund, RP; Wright, SD; Graziano, MP; Singh, SB; Roy, S; Cai, TQ Discovery of a potent and selective small molecule hGPR91 antagonist. Bioorg Med Chem Lett 21:3596-602 (2011) [PubMed]  Article 
Target
Name:
Succinate receptor 1
Synonyms:
G-protein coupled receptor 91 | GPR91 | P2Y purinoceptor 1-like | SUCNR1 | SUCR1_HUMAN
Type:
PROTEIN
Mol. Mass.:
38709.48
Organism:
Homo sapiens (Human)
Description:
ChEMBL_852820
Residue:
334
Sequence:
MLGIMAWNATCKNWLAAEAALEKYYLSIFYGIEFVVGVLGNTIVVYGYIFSLKNWNSSNIYLFNLSVSDLAFLCTLPMLIRSYANGNWIYGDVLCISNRYVLHANLYTSILFLTFISIDRYLIIKYPFREHLLQKKEFAILISLAIWVLVTLELLPILPLINPVITDNGTTCNDFASSGDPNYNLIYSMCLTLLGFLIPLFVMCFFYYKIALFLKQRNRQVATALPLEKPLNLVIMAVVIFSVLFTPYHVMRNVRIASRLGSWKQYQCTQVVINSFYIVTRPLAFLNSVINPVFYFLLGDHFRDMLMNQLRHNFKSLTSFSRWAHELLLSFREK
  
Inhibitor
Name:
BDBM50393142
Synonyms:
CHEMBL2153580
Type:
Small organic molecule
Emp. Form.:
C22H18ClFN4O2
Mol. Mass.:
424.855
SMILES:
Fc1ccc(cc1Cl)-c1cc(CNC(=O)CCCc2ccc3cccnc3n2)on1
Structure:
Search PDB for entries with ligand similarity: