Target
Tyrosine-protein phosphatase non-receptor type 12
Ligand
BDBM54792
Substrate
n/a
Meas. Tech.
ChEMBL_855962 (CHEMBL2161836)
IC50
35000±n/a nM
Citation
 Stanford, SMKrishnamurthy, DFalk, MDMessina, RDebnath, BLi, SLiu, TKazemi, RDahl, RHe, YYu, XChan, ACZhang, ZYBarrios, AMWoods, VLNeamati, NBottini, N Discovery of a novel series of inhibitors of lymphoid tyrosine phosphatase with activity in human T cells. J Med Chem 54:1640-54 (2011) [PubMed]  Article 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 12
Synonyms:
PTN12_HUMAN | PTP-PEST | PTPG1 | PTPN12 | Protein-tyrosine phosphatase G1 | Tyrosine-protein phosphatase non-receptor type 12 | Tyrosine-protein phosphatase non-receptor type 12 (PTP-PEST)
Type:
Protein
Mol. Mass.:
88089.78
Organism:
Homo sapiens (Human)
Description:
Q05209
Residue:
780
Sequence:
MEQVEILRKFIQRVQAMKSPDHNGEDNFARDFMRLRRLSTKYRTEKIYPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLYGEDPITFAPFKISCEDEQARTDYFIRTLLLEFQNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEHEDVPICIHCSAGCGRTGAICAIDYTWNLLKAGKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFEKQLQLYEIHGAQKIADGVNEINTENMVSSIEPEKQDSPPPKPPRTRSCLVEGDAKEEILQPPEPHPVPPILTPSPPSAFPTVTTVWQDNDRYHPKPVLHMVSSEQHSADLNRNYSKSTELPGKNESTIEQIDKKLERNLSFEIKKVPLQEGPKSFDGNTLLNRGHAIKIKSASPCIADKISKPQELSSDLNVGDTSQNSCVDCSVTQSNKVSVTPPEESQNSDTPPRPDRLPLDEKGHVTWSFHGPENAIPIPDLSEGNSSDINYQTRKTVSLTPSPTTQVETPDLVDHDNTSPLFRTPLSFTNPLHSDDSDSDERNSDGAVTQNKTNISTASATVSAATSTESISTRKVLPMSIARHNIAGTTHSGAEKDVDVSEDSPPPLPERTPESFVLASEHNTPVRSEWSELQSQERSEQKKSEGLITSENEKCDHPAGGIHYEMCIECPPTFSDKREQISENPTEATDIGFGNRCGKPKGPRDPPSEWT
  
Inhibitor
Name:
BDBM54792
Synonyms:
2-(3-cyano-5,8-dimethyl-quinolin-2-yl)sulfanyl-N-(2-ethyl-6-methyl-phenyl)ethanamide | 2-(3-cyano-5,8-dimethylquinolin-2-yl)sulfanyl-N-(2-ethyl-6-methylphenyl)acetamide | 2-[(3-cyano-5,8-dimethyl-2-quinolinyl)thio]-N-(2-ethyl-6-methylphenyl)acetamide | 2-[(3-cyano-5,8-dimethyl-2-quinolyl)thio]-N-(2-ethyl-6-methyl-phenyl)acetamide | CHEMBL1713374 | MLS-0412203.0001 | cid_1450182
Type:
Small organic molecule
Emp. Form.:
C23H23N3OS
Mol. Mass.:
389.513
SMILES:
CCc1cccc(C)c1NC(=O)CSc1nc2c(C)ccc(C)c2cc1C#N
Structure:
Search PDB for entries with ligand similarity: