Target
Glucagon-like peptide 1 receptor
Ligand
BDBM50393588
Substrate
n/a
Meas. Tech.
ChEMBL_855307 (CHEMBL2161791)
IC50
2700±n/a nM
Citation
 Liu, QLi, NYuan, YLu, HWu, XZhou, CHe, MSu, HZhang, MWang, JWang, BWang, YMa, DYe, YWeiss, HCGesing, ERLiao, JWang, MW Cyclobutane derivatives as novel nonpeptidic small molecule agonists of glucagon-like peptide-1 receptor. J Med Chem 55:250-67 (2012) [PubMed]  Article 
Target
Name:
Glucagon-like peptide 1 receptor
Synonyms:
GLP1R_RAT | Glp1r | Glpr
Type:
PROTEIN
Mol. Mass.:
52889.73
Organism:
Rattus norvegicus
Description:
ChEMBL_855307
Residue:
463
Sequence:
MAVTPSLLRLALLLLGAVGRAGPRPQGATVSLSETVQKWREYRHQCQRFLTEAPLLATGLFCNRTFDDYACWPDGPPGSFVNVSCPWYLPWASSVLQGHVYRFCTAEGIWLHKDNSSLPWRDLSECEESKQGERNSPEEQLLSLYIIYTVGYALSFSALVIASAILVSFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLGCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVFSEQRIFKLYLSIGWGVPLLFVIPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLVFIRVICIVIAKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFVKLFTELSFTSFQGFMVAVLYCFVNNEVQMEFRKSWERWRLERLNIQRDSSMKPLKCPTSSVSSGATVGSSVYAATCQNSCS
  
Inhibitor
Name:
BDBM50393588
Synonyms:
CHEMBL2158407
Type:
Small organic molecule
Emp. Form.:
C50H56N4O16
Mol. Mass.:
968.9968
SMILES:
CCC(=O)Oc1ccc(cc1OC)[C@H]1[C@@](NC(=O)c2ccc(NC(=O)OC(C)(C)C)cc2)([C@@H](c2ccc(OC(=O)CC)c(OC)c2)[C@]1(NC(=O)c1ccc(NC(=O)OC(C)(C)C)cc1)C(O)=O)C(O)=O |r,wU:13.13,46.50,32.34,14.15,wD:46.68,14.71,(30.57,-26.73,;31.89,-25.94,;31.86,-24.4,;33.18,-23.6,;30.51,-23.65,;29.19,-24.44,;29.22,-25.99,;27.9,-26.78,;26.56,-26.03,;26.52,-24.49,;27.83,-23.7,;27.8,-22.16,;29.12,-21.36,;25.24,-26.82,;25.24,-28.36,;26.31,-29.47,;26.29,-31.01,;24.96,-31.77,;27.62,-31.79,;27.6,-33.33,;28.93,-34.11,;30.27,-33.35,;31.6,-34.13,;31.59,-35.67,;32.92,-36.45,;30.25,-36.43,;30.24,-37.97,;28.9,-38.73,;31.57,-38.75,;30.25,-39.51,;30.28,-31.8,;28.95,-31.03,;23.7,-28.36,;22.9,-29.65,;23.63,-31,;22.84,-32.33,;21.29,-32.29,;20.49,-33.61,;18.95,-33.57,;18.21,-32.22,;18.15,-34.89,;16.61,-34.85,;20.56,-30.94,;19.02,-30.9,;18.28,-29.55,;21.36,-29.63,;23.69,-26.82,;22.93,-25.49,;23.7,-24.15,;25.24,-24.15,;22.92,-22.82,;23.7,-21.49,;22.93,-20.16,;21.39,-20.16,;20.61,-18.83,;21.38,-17.49,;20.61,-16.16,;22.92,-17.49,;23.69,-16.15,;25.23,-16.15,;22.92,-14.82,;24.45,-14.81,;20.62,-21.5,;21.39,-22.83,;22.15,-26.82,;21.38,-25.49,;21.38,-28.15,;26.77,-28.36,;27.54,-29.69,;27.29,-27.3,)|
Structure:
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