Reaction Details Report a problem with these data
Target
Prostaglandin G/H synthase 2
Ligand
BDBM50394419
Substrate
n/a
Meas. Tech.
ChEMBL_854783 (CHEMBL2161914)
IC50
550±n/a nM
Citation
 Yang, Z; Truong, TN; Pham, TA; Lee, JW; Kim, SS; Park, H Synthesis of 1,5-diarylhaloimidazole analogs and their inhibitory activities against PGE2 production from LPS-treated RAW 264.7 cells. Bioorg Med Chem 20:6256-9 (2012) [PubMed]  Article 
Target
Name:
Prostaglandin G/H synthase 2
Synonyms:
Cox-2 | Cox2 | Cyclooxygenase-2 | Cyclooxygenase-2 (COX-2) | Glucocorticoid-regulated inflammatory cyclooxygenase | Gripghs | Macrophage activation-associated marker protein P71/73 | PES-2 | PGH synthase 2 | PGH2_MOUSE | PGHS-2 | PHS II | Pghs-b | Prostaglandin G/H synthase (cyclooxygenase) | Prostaglandin H2 synthase 2 | Prostaglandin-endoperoxide synthase 2 | Ptgs2 | TIS10 protein | Tis10
Type:
Protein
Mol. Mass.:
69020.39
Organism:
Mus musculus (Mouse)
Description:
Q05769
Residue:
604
Sequence:
MLFRAVLLCAALGLSQAANPCCSNPCQNRGECMSTGFDQYKCDCTRTGFYGENCTTPEFLTRIKLLLKPTPNTVHYILTHFKGVWNIVNNIPFLRSLIMKYVLTSRSYLIDSPPTYNVHYGYKSWEAFSNLSYYTRALPPVADDCPTPMGVKGNKELPDSKEVLEKVLLRREFIPDPQGSNMMFAFFAQHFTHQFFKTDHKRGPGFTRGLGHGVDLNHIYGETLDRQHKLRLFKDGKLKYQVIGGEVYPPTVKDTQVEMIYPPHIPENLQFAVGQEVFGLVPGLMMYATIWLREHNRVCDILKQEHPEWGDEQLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFDPELLFNQQFQYQNRIASEFNTLYHWHPLLPDTFNIEDQEYSFKQFLYNNSILLEHGLTQFVESFTRQIAGRVAGGRNVPIAVQAVAKASIDQSREMKYQSLNEYRKRFSLKPYTSFEELTGEKEMAAELKALYSDIDVMELYPALLVEKPRPDAIFGETMVELGAPFSLKGLMGNPICSPQYWKPSTFGGEVGFKIINTASIQSLICNNVKGCPFTSFNVQDPQPTKTATINASASHSRLDDINPTVLIKRRSTEL
  
Inhibitor
Name:
BDBM50394419
Synonyms:
CHEMBL2158172
Type:
Small organic molecule
Emp. Form.:
C16H10Cl2F2N2O2S
Mol. Mass.:
403.231
SMILES:
CS(=O)(=O)c1ccc(cc1)-c1c(Cl)nc(Cl)n1-c1ccc(F)cc1F |(23.95,-3.27,;23.94,-1.73,;24.7,-.38,;25.43,-2.12,;22.61,-.97,;21.27,-1.74,;19.94,-.98,;19.94,.57,;21.26,1.34,;22.6,.58,;18.69,1.46,;17.22,.98,;16.75,-.49,;16.31,2.22,;17.21,3.47,;16.73,4.94,;18.68,3,;20,3.78,;21.34,3.02,;22.67,3.8,;22.66,5.34,;23.98,6.12,;21.31,6.1,;19.99,5.32,;18.65,6.07,)|
Structure:
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