Target
Ceramide glucosyltransferase
Ligand
BDBM50394807
Substrate
n/a
Meas. Tech.
ChEMBL_859947 (CHEMBL2167350)
IC50
4±n/a nM
Citation
 Richards, SLarson, CJKoltun, ESHanel, AChan, VNachtigall, JHarrison, AAay, NDu, HArcalas, AGalan, AZhang, JZhang, WWon, KATam, DQian, FWang, TFinn, POgilvie, KRosen, JAoyama, RPlonowski, ACancilla, BBentzien, FYakes, MMohan, RLamb, PNuss, JKearney, P Discovery and characterization of an inhibitor of glucosylceramide synthase. J Med Chem 55:4322-35 (2012) [PubMed]  Article 
Target
Name:
Ceramide glucosyltransferase
Synonyms:
CEGT_HUMAN | GCS | GLCT-1 | Glucosylceramide synthase | UDP-glucose ceramide glucosyltransferase | UDP-glucose:N-acylsphingosine D-glucosyltransferase | UGCG
Type:
PROTEIN
Mol. Mass.:
44859.25
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1435474
Residue:
394
Sequence:
MALLDLALEGMAVFGFVLFLVLWLMHFMAIIYTRLHLNKKATDKQPYSKLPGVSLLKPLKGVDPNLINNLETFFELDYPKYEVLLCVQDHDDPAIDVCKKLLGKYPNVDARLFIGGKKVGINPKINNLMPGYEVAKYDLIWICDSGIRVIPDTLTDMVNQMTEKVGLVHGLPYVADRQGFAATLEQVYFGTSHPRYYISANVTGFKCVTGMSCLMRKDVLDQAGGLIAFAQYIAEDYFMAKAIADRGWRFAMSTQVAMQNSGSYSISQFQSRMIRWTKLRINMLPATIICEPISECFVASLIIGWAAHHVFRWDIMVFFMCHCLAWFIFDYIQLRGVQGGTLCFSKLDYAVAWFIRESMTIYIFLSALWDPTISWRTGRYRLRCGGTAEEILDV
  
Inhibitor
Name:
BDBM50394807
Synonyms:
CHEMBL2163825
Type:
Small organic molecule
Emp. Form.:
C26H27Cl4N3O2
Mol. Mass.:
555.323
SMILES:
NC1C[C@@H]2CC[C@H](C1)N2C(=O)[C@H](Cc1ccc(Cl)cc1Cl)NC(=O)C1(CC1)c1ccc(Cl)cc1Cl |r,TLB:9:8:1.2.7:5.4|
Structure:
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