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TargetLysine-specific demethylase 2A
LigandBDBM50395076
Substrate/Competitorn/a
Meas. Tech.ChEMBL_859421
Ki 85000±n/a nM
Citation Rose, NRWoon, ECTumber, AWalport, LJChowdhury, RLi, XSKing, ONLejeune, CNg, SSKrojer, TChan, MCRydzik, AMHopkinson, RJChe, KHDaniel, MStrain-Damerell, CGileadi, CKochan, GLeung, IKDunford, JYeoh, KKRatcliffe, PJBurgess-Brown, Nvon Delft, FMuller, SMarsden, BBrennan, PEMcDonough, MAOppermann, UKlose, RJSchofield, CJKawamura, A Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases. J Med Chem55:6639-43 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Lysine-specific demethylase 2A
Name:Lysine-specific demethylase 2A
Synonyms:F-box and leucine-rich repeat protein 11 | Lysine-specific demethylase 2A (KDM2A)
Type:PROTEIN
Mol. Mass.:132809.04
Organism:Homo sapiens
Description:Q9Y2K7
Residue:1162
Sequence:
MEPEEERIRYSQRLRGTMRRRYEDDGISDDEIEGKRTFDLEEKLHTNKYNANFVTFMEGK
DFNVEYIQRGGLRDPLIFKNSDGLGIKMPDPDFTVNDVKMCVGSRRMVDVMDVNTQKGIE
MTMAQWTRYYETPEEEREKLYNVISLEFSHTRLENMVQRPSTVDFIDWVDNMWPRHLKES
QTESTNAILEMQYPKVQKYCLMSVRGCYTDFHVDFGGTSVWYHIHQGGKVFWLIPPTAHN
LELYENWLLSGKQGDIFLGDRVSDCQRIELKQGYTFVIPSGWIHAVYTPTDTLVFGGNFL
HSFNIPMQLKIYNIEDRTRVPNKFRYPFYYEMCWYVLERYVYCITNRSHLTKEFQKESLS
MDLELNGLESGNGDEEAVDREPRRLSSRRSVLTSPVANGVNLDYDGLGKTCRSLPSLKKT
LAGDSSSDCSRGSHNGQVWDPQCAPRKDRQVHLTHFELEGLRCLVDKLESLPLHKKCVPT
GIEDEDALIADVKILLEELANSDPKLALTGVPIVQWPKRDKLKFPTRPKVRVPTIPITKP
HTMKPAPRLTPVRPAAASPIVSGARRRRVRCRKCKACVQGECGVCHYCRDMKKFGGPGRM
KQSCVLRQCLAPRLPHSVTCSLCGEVDQNEETQDFEKKLMECCICNEIVHPGCLQMDGEG
LLNEELPNCWECPKCYQEDSSEKAQKRKMEESDEEAVQAKVLRPLRSCDEPLTPPPHSPT
SMLQLIHDPVSPRGMVTRSSPGAGPSDHHSASRDERFKRRQLLRLQATERTMVREKENNP
SGKKELSEVEKAKIRGSYLTVTLQRPTKELHGTSIVPKLQAITASSANLRHSPRVLVQHC
PARTPQRGDEEGLGGEEEEEEEEEEEDDSAEEGGAARLNGRGSWAQDGDESWMQREVWMS
VFRYLSRRELCECMRVCKTWYKWCCDKRLWTKIDLSRCKAIVPQALSGIIKRQPVSLDLS
WTNISKKQLTWLVNRLPGLKDLLLAGCSWSAVSALSTSSCPLLRTLDLRWAVGIKDPQIR
DLLTPPADKPGQDNRSKLRNMTDFRLAGLDITDATLRLIIRHMPLLSRLDLSHCSHLTDQ
SSNLLTAVGSSTRYSLTELNMAGCNKLTDQTLIYLRRIANVTLIDLRGCKQITRKACEHF
ISDLSINSLYCLSDEKLIQKIS
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  Blast E-value cutoff:
BDBM50395076
NameBDBM50395076
Synonyms:CHEMBL2164243
TypeSmall organic molecule
Emp. Form.C6H12N2O3
Mol. Mass.160.1711
SMILESCN(C)NC(=O)CCC(O)=O
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a