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Target
Gamma-butyrobetaine dioxygenase
Ligand
BDBM50395078
Substrate
n/a
Meas. Tech.
ChEMBL_859436 (CHEMBL2167514)
IC50
>100000±n/a nM
Citation
 Rose, NR; Woon, EC; Tumber, A; Walport, LJ; Chowdhury, R; Li, XS; King, ON; Lejeune, C; Ng, SS; Krojer, T; Chan, MC; Rydzik, AM; Hopkinson, RJ; Che, KH; Daniel, M; Strain-Damerell, C; Gileadi, C; Kochan, G; Leung, IK; Dunford, J; Yeoh, KK; Ratcliffe, PJ; Burgess-Brown, N; von Delft, F; Muller, S; Marsden, B; Brennan, PE; McDonough, MA; Oppermann, U; Klose, RJ; Schofield, CJ; Kawamura, A Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases. J Med Chem 55:6639-43 (2012) [PubMed]  Article 
Target
Name:
Gamma-butyrobetaine dioxygenase
Synonyms:
BBH | BBOX | BBOX1 | BODG_HUMAN | Gamma-BBH | Gamma-butyrobetaine hydroxylase | Gamma-butyrobetaine,2-oxoglutarate dioxygenase
Type:
PROTEIN
Mol. Mass.:
44715.93
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1434107
Residue:
387
Sequence:
MACTIQKAEALDGAHLMQILWYDEEESLYPAVWLRDNCPCSDCYLDSAKARKLLVEALDVNIGIKGLIFDRKKVYITWPDEHYSEFQADWLKKRCFSKQARAKLQRELFFPECQYWGSELQLPTLDFEDVLRYDEHAYKWLSTLKKVGIVRLTGASDKPGEVSKLGKRMGFLYLTFYGHTWQVQDKIDANNVAYTTGKLSFHTDYPALHHPPGVQLLHCIKQTVTGGDSEIVDGFNVCQKLKKNNPQAFQILSSTFVDFTDIGVDYCDFSVQSKHKIIELDDKGQVVRINFNNATRDTIFDVPVERVQPFYAALKEFVDLMNSKESKFTFKMNPGDVITFDNWRLLHGRRSYEAGTEISRHLEGAYADWDVVMSRLRILRQRVENGN
  
Inhibitor
Name:
BDBM50395078
Synonyms:
CHEMBL2164245
Type:
Small organic molecule
Emp. Form.:
C5H10N2O3
Mol. Mass.:
146.1445
SMILES:
CNNC(=O)CCC(O)=O
Structure:
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