Reaction Details Report a problem with these data
Target
Carboxypeptidase B2
Ligand
BDBM50395732
Substrate
n/a
Meas. Tech.
ChEMBL_860207 (CHEMBL2168947)
IC50
200±n/a nM
Citation
 Yoshimoto, N; Sasaki, T; Sugimoto, K; Ishii, H; Yamamoto, K Design and characterization of a selenium-containing inhibitor of activated thrombin-activatable fibrinolysis inhibitor (TAFIa), a zinc-containing metalloprotease. J Med Chem 55:7696-705 (2012) [PubMed]  Article 
Target
Name:
Carboxypeptidase B2
Synonyms:
CBPB2_HUMAN | CPB2 | CPU | Carboxypeptidase B2 | Carboxypeptidase B2 isoform A | Carboxypeptidase U | Plasma carboxypeptidase B | TAFI | Thrombin-activable fibrinolysis inhibitor | pCPB
Type:
Enzyme
Mol. Mass.:
48432.74
Organism:
Homo sapiens (Human)
Description:
Q96IY4
Residue:
423
Sequence:
MKLCSLAVLVPIVLFCEQHVFAFQSGQVLAALPRTSRQVQVLQNLTTTYEIVLWQPVTADLIVKKKQVHFFVNASDVDNVKAHLNVSGIPCSVLLADVEDLIQQQISNDTVSPRASASYYEQYHSLNEIYSWIEFITERHPDMLTKIHIGSSFEKYPLYVLKVSGKEQAAKNAIWIDCGIHAREWISPAFCLWFIGHITQFYGIIGQYTNLLRLVDFYVMPVVNVDGYDYSWKKNRMWRKNRSFYANNHCIGTDLNRNFASKHWCEEGASSSSCSETYCGLYPESEPEVKAVASFLRRNINQIKAYISMHSYSQHIVFPYSYTRSKSKDHEELSLVASEAVRAIEKISKNTRYTHGHGSETLYLAPGGGDDWIYDLGIKYSFTIELRDTGTYGFLLPERYIKPTCREAFAAVSKIAWHVIRNV
  
Inhibitor
Name:
BDBM50395732
Synonyms:
CHEMBL2164462
Type:
Small organic molecule
Emp. Form.:
C18H22N4O4Se2
Mol. Mass.:
516.31
SMILES:
Nc1ccc(CC(C[Se][Se]CC(Cc2ccc(N)nc2)C(O)=O)C(O)=O)cn1
Structure:
Search PDB for entries with ligand similarity: