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Target
Glutathione peroxidase 1
Ligand
BDBM50395834
Substrate
n/a
Meas. Tech.
ChEMBL_861052 (CHEMBL2166452)
IC50
169000±n/a nM
Citation
 Schulz, R; Emmrich, T; Lemmerhirt, H; Leffler, U; Sydow, K; Hirt, C; Kiefer, T; Link, A; Bednarski, PJ Identification of a glutathione peroxidase inhibitor that reverses resistance to anticancer drugs in human B-cell lymphoma cell lines. Bioorg Med Chem Lett 22:6712-5 (2012) [PubMed]  Article 
Target
Name:
Glutathione peroxidase 1
Synonyms:
Cellular glutathione peroxidase | GPX1 | GPX1_HUMAN | GPx-1 | GSHPx-1 | Glutathione peroxidase 1 (GPx)
Type:
Enzyme
Mol. Mass.:
21937.89
Organism:
Homo sapiens (Human)
Description:
P07203
Residue:
202
Sequence:
MCAARLAAAAAAAQSVYAFSARPLAGGEPVSLGSLRGKVLLIENVASLGTTVRDYTQMNELQRRLGPRGLVVLGFPCNQFGHQENAKNEEILNSLKYVRPGGGFEPNFMLFEKCEVNGAGAHPLFAFLREALPAPSDDATALMTDPKLITWSPVCRNDVAWNFEKFLVGPDGVPLRRYSRRFQTIDIEPDIEALLSQGPSCA
  
Inhibitor
Name:
BDBM50395834
Synonyms:
CHEMBL2165394
Type:
Small organic molecule
Emp. Form.:
C13H14N4O2
Mol. Mass.:
258.2759
SMILES:
Cc1nccn1CC(=O)N\N=C\c1ccc(O)cc1
Structure:
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