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TargetEstradiol 17-beta-dehydrogenase 1 (17beta-HSD1)
LigandBDBM50396084
Substrate/Competitorn/a
Meas. Tech.ChEMBL_861311
IC50 11±n/a nM
Citation Spadaro, AFrotscher, MHartmann, RW Optimization of hydroxybenzothiazoles as novel potent and selective inhibitors of 17ß-HSD1. J Med Chem55:2469-73 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Estradiol 17-beta-dehydrogenase 1 (17beta-HSD1)
Name:Estradiol 17-beta-dehydrogenase 1
Synonyms:17-beta-HSD 1 | 17-beta-hydroxysteroid dehydrogenase type 1 | 20 alpha-hydroxysteroid dehydrogenase | 20-alpha-HSD | E2DH | Estradiol 17-beta-dehydrogenase 1 | Placental 17-beta-hydroxysteroid dehydrogenase
Type:Enzyme
Mol. Mass.:34945.13
Organism:Homo sapiens (Human)
Description:P14061
Residue:328
Sequence:
MARTVVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSL
ETLQLDVRDSKSVAAARERVTEGRVDVLVCNAGLGLLGPLEALGEDAVASVLDVNVVGTV
RMLQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLLPFGVH
LSLIECGPVHTAFMEKVLGSPEEVLDRTDIHTFHRFYQYLAHSKQVFREAAQNPEEVAEV
FLTALRAPKPTLRYFTTERFLPLLRMRLDDPSGSNYVTAMHREVFGDVPAKAEAGAEAGG
GAGPGAEDEAGRGAVGDPELGDPPAAPQ
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50396084
NameBDBM50396084
Synonyms:CHEMBL2170750
TypeSmall organic molecule
Emp. Form.C14H8FNO3S
Mol. Mass.289.282
SMILESOc1ccc2nc(sc2c1)C(=O)c1ccc(F)c(O)c1
Structure
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