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Target
2-Hydroxyacid oxidase 2
Ligand
BDBM50396204
Substrate
n/a
Meas. Tech.
ChEMBL_863190 (CHEMBL2175914)
IC50
2000±n/a nM
Citation
 Barawkar, DA; Bandyopadhyay, A; Deshpande, A; Koul, S; Kandalkar, S; Patil, P; Khose, G; Vyas, S; Mone, M; Bhosale, S; Singh, U; De, S; Meru, A; Gundu, J; Chugh, A; Palle, VP; Mookhtiar, KA; Vacca, JP; Chakravarty, PK; Nargund, RP; Wright, SD; Roy, S; Graziano, MP; Cully, D; Cai, TQ; Singh, SB Discovery of pyrazole carboxylic acids as potent inhibitors of rat long chain L-2-hydroxy acid oxidase. Bioorg Med Chem Lett 22:4341-7 (2012) [PubMed]  Article 
Target
Name:
2-Hydroxyacid oxidase 2
Synonyms:
(S)-2-hydroxy-acid oxidase, peroxisomal | HAOX2_RAT | Hao2 | Hao3 | Haox2 | Hydroxyacid oxidase 2 | Long chain alpha-hydroxy acid oxidase | Long-chain L-2-hydroxy acid oxidase
Type:
PROTEIN
Mol. Mass.:
39204.34
Organism:
Rattus norvegicus
Description:
ChEMBL_863190
Residue:
353
Sequence:
MPLVCLADFKAHAQKQLSKTSWDFIEGEADDGITYSENIAAFKRIRLRPRYLRDMSKVDTRTTIQGQEISAPICISPTAFHSIAWPDGEKSTARAAQEANICYVISSYASYSLEDIVAAAPEGFRWFQLYMKSDWDFNKQMVQRAEALGFKALVITIDTPVLGNRRRDKRNQLNLEANILLKDLRALKEEKPTQSVPVSFPKASFCWNDLSLLQSITRLPIILKGILTKEDAELAMKHNVQGIVVSNHGGRQLDEVSASIDALREVVAAVKGKIEVYMDGGVRTGTDVLKALALGARCIFLGRPILWGLACKGEDGVKEVLDILTAELHRCMTLSGCQSVAEISPDLIQFSRL
  
Inhibitor
Name:
BDBM50396204
Synonyms:
CHEMBL2172037
Type:
Small organic molecule
Emp. Form.:
C19H15F3N2O3
Mol. Mass.:
376.3292
SMILES:
Cc1[nH]nc(C(O)=O)c1Cc1ccc(cc1)-c1ccc(OC(F)(F)F)cc1
Structure:
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