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Target
Diacylglycerol lipase-alpha
Ligand
BDBM50240877
Substrate
n/a
Meas. Tech.
ChEMBL_863914 (CHEMBL2176398)
IC50
65000±n/a nM
Citation
 Johnston, M; Bhatt, SR; Sikka, S; Mercier, RW; West, JM; Makriyannis, A; Gatley, SJ; Duclos, RI Assay and inhibition of diacylglycerol lipase activity. Bioorg Med Chem Lett 22:4585-92 (2012) [PubMed]  Article 
Target
Name:
Diacylglycerol lipase-alpha
Synonyms:
C11orf11 | DAGLA | DGLA_HUMAN | KIAA0659 | NSDDR | Sn1-specific diacylglycerol lipase alpha
Type:
PROTEIN
Mol. Mass.:
114947.74
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1449471
Residue:
1042
Sequence:
MPGIVVFRRRWSVGSDDLVLPAIFLFLLHTTWFVILSVVLFGLVYNPHEACSLNLVDHGRGYLGILLSCMIAEMAIIWLSMRGGILYTEPRDSMQYVLYVRLAILVIEFIYAIVGIVWLTQYYTSCNDLTAKNVTLGMVVCNWVVILSVCITVLCVFDPTGRTFVKLRATKRRQRNLRTYNLRHRLEEGQATSWSRRLKVFLCCTRTKDSQSDAYSEIAYLFAEFFRDLDIVPSDIIAGLVLLRQRQRAKRNAVLDEANNDILAFLSGMPVTRNTKYLDLKNSQEMLRYKEVCYYMLFALAAYGWPMYLMRKPACGLCQLARSCSCCLCPARPRFAPGVTIEEDNCCGCNAIAIRRHFLDENMTAVDIVYTSCHDAVYETPFYVAVDHDKKKVVISIRGTLSPKDALTDLTGDAERLPVEGHHGTWLGHKGMVLSAEYIKKKLEQEMVLSQAFGRDLGRGTKHYGLIVVGHSLGAGTAAILSFLLRPQYPTLKCFAYSPPGGLLSEDAMEYSKEFVTAVVLGKDLVPRIGLSQLEGFRRQLLDVLQRSTKPKWRIIVGATKCIPKSELPEEVEVTTLASTRLWTHPSDLTIALSASTPLYPPGRIIHVVHNHPAEQCCCCEQEEPTYFAIWGDNKAFNEVIISPAMLHEHLPYVVMEGLNKVLENYNKGKTALLSAAKVMVSPTEVDLTPELIFQQQPLPTGPPMPTGLALELPTADHRNSSVRSKSQSEMSLEGFSEGRLLSPVVAAAARQDPVELLLLSTQERLAAELQARRAPLATMESLSDTESLYSFDSRRSSGFRSIRGSPSLHAVLERDEGHLFYIDPAIPEENPSLSSRTELLAADSLSKHSQDTQPLEAALGSGGVTPERPPSAAANDEEEEVGGGGGGPASRGELALHNGRLGDSPSPQVLEFAEFIDSLFNLDSKSSSFQDLYCMVVPESPTSDYAEGPKSPSQQEILLRAQFEPNLVPKPPRLFAGSADPSSGISLSPSFPLSSSGELMDLTPTGLSSQECLAADKIRTSTPTGHGASPAKQDELVISAR
  
Inhibitor
Name:
BDBM50240877
Synonyms:
CHEMBL158897 | Quinolyl derivatives | cyclohexanone O-6-((cyclohexylideneaminooxy)carbonylamino)hexylcarbamoyl oxime
Type:
Small organic molecule
Emp. Form.:
C20H34N4O4
Mol. Mass.:
394.5084
SMILES:
O=[#6](-[#7]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#7]-[#6](=O)-[#8]\[#7]=[#6]-1\[#6]-[#6]-[#6]-[#6]-[#6]-1)-[#8]\[#7]=[#6]-1\[#6]-[#6]-[#6]-[#6]-[#6]-1
Structure:
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