Reaction Details Report a problem with these data
Target
Vasopressin V2 receptor
Ligand
BDBM50397214
Substrate
n/a
Meas. Tech.
ChEMBL_864210 (CHEMBL2175262)
Ki
25.3±n/a nM
Citation
 Loison, S; Cottet, M; Orcel, H; Adihou, H; Rahmeh, R; Lamarque, L; Trinquet, E; Kellenberger, E; Hibert, M; Durroux, T; Mouillac, B; Bonnet, D Selective fluorescent nonpeptidic antagonists for vasopressin V2 GPCR: application to ligand screening and oligomerization assays. J Med Chem 55:8588-602 (2012) [PubMed]  Article 
Target
Name:
Vasopressin V2 receptor
Synonyms:
ADHR | AVPR V2 | AVPR2 | Antidiuretic hormone receptor | DIR | DIR3 | Renal-type arginine vasopressin receptor | V2R | V2R_HUMAN | VASOPRESSIN V2 | Vasopressin V2 receptor | Vasopressin receptor
Type:
Receptor
Mol. Mass.:
40295.28
Organism:
Homo sapiens (Human)
Description:
P30518
Residue:
371
Sequence:
MLMASTTSAVPGHPSLPSLPSNSSQERPLDTRDPLLARAELALLSIVFVAVALSNGLVLAALARRGRRGHWAPIHVFIGHLCLADLAVALFQVLPQLAWKATDRFRGPDALCRAVKYLQMVGMYASSYMILAMTLDRHRAICRPMLAYRHGSGAHWNRPVLVAWAFSLLLSLPQLFIFAQRNVEGGSGVTDCWACFAEPWGRRTYVTWIALMVFVAPTLGIAACQVLIFREIHASLVPGPSERPGGRRRGRRTGSPGEGAHVSAAVAKTVRMTLVIVVVYVLCWAPFFLVQLWAAWDPEAPLEGAPFVLLMLLASLNSCTNPWIYASFSSSVSSELRSLLCCARGRTPPSLGPQDESCTTASSSLAKDTSS
  
Inhibitor
Name:
BDBM50397214
Synonyms:
CHEMBL2172390
Type:
Small organic molecule
Emp. Form.:
C57H55N5O8S2
Mol. Mass.:
1002.205
SMILES:
CCN(CC)c1ccc2c(-c3ccc(cc3S([O-])(=O)=O)S(=O)(=O)NC3CCCN(C(=O)c4ccc(NC(=O)c5ccccc5-c5ccccc5)cc4)c4ccccc34)c3ccc(cc3oc2c1)=[N+](CC)CC |(14.53,-35.6,;13.74,-36.92,;14.49,-38.27,;16.03,-38.29,;16.82,-36.97,;13.7,-39.59,;14.45,-40.93,;13.66,-42.24,;12.14,-42.22,;11.45,-43.49,;12.21,-44.83,;11.44,-46.16,;12.21,-47.5,;13.74,-47.5,;14.52,-46.17,;13.76,-44.83,;14.53,-43.5,;16.07,-43.51,;14.92,-42,;13.19,-42.73,;14.5,-48.83,;15.83,-48.06,;15.83,-49.6,;13.62,-50.1,;14.24,-51.47,;15.78,-51.46,;16.77,-52.65,;16.43,-54.17,;15.03,-54.85,;15.02,-56.42,;13.68,-57.19,;16.35,-57.2,;16.34,-58.74,;17.67,-59.51,;19.01,-58.74,;20.34,-59.52,;21.67,-58.75,;21.68,-57.21,;23,-59.52,;23,-61.07,;24.33,-61.85,;25.67,-61.07,;25.67,-59.53,;24.33,-58.76,;24.34,-57.22,;25.67,-56.46,;25.67,-54.92,;24.34,-54.14,;23,-54.93,;23,-56.46,;19.02,-57.21,;17.7,-56.43,;13.65,-54.2,;12.53,-55.28,;11.04,-54.85,;10.66,-53.34,;11.78,-52.25,;13.28,-52.69,;9.81,-43.52,;9.04,-44.84,;7.51,-44.83,;6.75,-43.49,;7.53,-42.18,;9.06,-42.19,;9.84,-40.86,;11.38,-40.88,;12.17,-39.56,;5.21,-43.47,;4.46,-42.13,;2.92,-42.12,;4.43,-44.8,;2.89,-44.78,)|
Structure:
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