Reaction Details Report a problem with these data
Target
Eukaryotic initiation factor 4A-I
Ligand
BDBM50397420
Substrate
n/a
Meas. Tech.
ChEMBL_864983 (CHEMBL2176057)
EC50
15±n/a nM
Citation
 Liu, T; Nair, SJ; Lescarbeau, A; Belani, J; Peluso, S; Conley, J; Tillotson, B; O'Hearn, P; Smith, S; Slocum, K; West, K; Helble, J; Douglas, M; Bahadoor, A; Ali, J; McGovern, K; Fritz, C; Palombella, VJ; Wylie, A; Castro, AC; Tremblay, MR Synthetic silvestrol analogues as potent and selective protein synthesis inhibitors. J Med Chem 55:8859-78 (2012) [PubMed]  Article 
Target
Name:
Eukaryotic initiation factor 4A-I
Synonyms:
ATP-dependent RNA helicase eIF4A-1 | DDX2A | EIF4A | EIF4A1 | IF4A1_HUMAN | eIF-4A-I | eIF4A-I
Type:
PROTEIN
Mol. Mass.:
46146.87
Organism:
Homo sapiens (Human)
Description:
ChEMBL_864983
Residue:
406
Sequence:
MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI
  
Inhibitor
Name:
BDBM50397420
Synonyms:
CHEMBL2170563
Type:
Small organic molecule
Emp. Form.:
C28H28ClNO6
Mol. Mass.:
509.978
SMILES:
COc1ccc(cc1)[C@@]12Oc3cc(Cl)cc(OC)c3[C@]1(O)[C@H](O)[C@@H]([C@H]2c1ccccc1)C(=O)N(C)C |r|
Structure:
Search PDB for entries with ligand similarity: