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Target
Apoptosis regulator Bcl-2
Ligand
BDBM50397467
Substrate
n/a
Meas. Tech.
ChEMBL_862012 (CHEMBL2173962)
IC50
2543±n/a nM
Citation
 Chen, J; Zhou, H; Aguilar, A; Liu, L; Bai, L; McEachern, D; Yang, CY; Meagher, JL; Stuckey, JA; Wang, S Structure-based discovery of BM-957 as a potent small-molecule inhibitor of Bcl-2 and Bcl-xL capable of achieving complete tumor regression. J Med Chem 55:8502-14 (2012) [PubMed]  Article 
Target
Name:
Apoptosis regulator Bcl-2
Synonyms:
Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein
Type:
Homodimer or heterodimer
Mol. Mass.:
26269.11
Organism:
Homo sapiens (Human)
Description:
P10415
Residue:
239
Sequence:
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
  
Inhibitor
Name:
BDBM50397467
Synonyms:
CHEMBL2170843
Type:
Small organic molecule
Emp. Form.:
C44H52ClN7O5S2
Mol. Mass.:
858.511
SMILES:
CN1CCN(CCCNC(=O)c2c(C)n(C)c(c2-c2cccc(c2)N2CCN(CC2)c2ccc(NS(=O)(=O)c3cccc(c3)S(C)(=O)=O)cc2)-c2ccc(Cl)cc2)CC1
Structure:
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