Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetBromodomain-containing protein 3
LigandBDBM50397671
Substrate/Competitorn/a
Meas. Tech.ChEMBL_873615
IC50 630.96±n/a nM
Citation Seal, JLamotte, YDonche, FBouillot, AMirguet, OGellibert, FNicodeme, EKrysa, GKirilovsky, JBeinke, SMcCleary, SRioja, IBamborough, PChung, CWGordon, LLewis, TWalker, ALCutler, LLugo, DWilson, DMWitherington, JLee, KPrinjha, RK Identification of a novel series of BET family bromodomain inhibitors: binding mode and profile of I-BET151 (GSK1210151A). Bioorg Med Chem Lett22:2968-72 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Bromodomain-containing protein 3
Name:Bromodomain-containing protein 3
Synonyms:Bromodomain-containing protein 3 | Bromodomain-containing protein 3 (BRD3) | RING3-like protein
Type:Protein
Mol. Mass.:79571.81
Organism:Homo sapiens (Human)
Description:Q15059
Residue:726
Sequence:
MSTATTVAPAGIPATPGPVNPPPPEVSNPSKPGRKTNQLQYMQNVVVKTLWKHQFAWPFY
QPVDAIKLNLPDYHKIIKNPMDMGTIKKRLENNYYWSASECMQDFNTMFTNCYIYNKPTD
DIVLMAQALEKIFLQKVAQMPQEEVELLPPAPKGKGRKPAAGAQSAGTQQVAAVSSVSPA
TPFQSVPPTVSQTPVIAATPVPTITANVTSVPVPPAAAPPPPATPIVPVVPPTPPVVKKK
GVKRKADTTTPTTSAITASRSESPPPLSDPKQAKVVARRESGGRPIKPPKKDLEDGEVPQ
HAGKKGKLSEHLRYCDSILREMLSKKHAAYAWPFYKPVDAEALELHDYHDIIKHPMDLST
VKRKMDGREYPDAQGFAADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDEPV
EAPALPAPAAPMVSKGAESSRSSEESSSDSGSSDSEEERATRLAELQEQLKAVHEQLAAL
SQAPVNKPKKKKEKKEKEKKKKDKEKEKEKHKVKAEEEKKAKVAPPAKQAQQKKAPAKKA
NSTTTAGRQLKKGGKQASASYDSEEEEEGLPMSYDEKRQLSLDINRLPGEKLGRVVHIIQ
SREPSLRDSNPDEIEIDFETLKPTTLRELERYVKSCLQKKQRKPFSASGKKQAAKSKEEL
AQEKKKELEKRLQDVSGQLSSSKKPARKEKPGSAPSGGPSRLSSSSSSESGSSSSSGSSS
DSSDSE
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50397671
NameBDBM50397671
Synonyms:CHEMBL2017289
TypeSmall organic molecule
Emp. Form.C24H22N4O3
Mol. Mass.414.4565
SMILESCOc1cc2c3n([C@@H](C)c4ccccc4)c(=O)[nH]c3cnc2cc1-c1c(C)noc1C |r,wU:7.7,(17.14,-40.4,;17.14,-41.94,;18.48,-42.71,;19.81,-41.94,;21.14,-42.7,;22.47,-41.93,;22.77,-40.43,;22,-39.09,;20.46,-39.09,;22.77,-37.76,;24.31,-37.76,;25.08,-36.43,;24.31,-35.1,;22.76,-35.1,;22,-36.43,;24.3,-40.25,;25.05,-38.91,;24.93,-41.65,;23.8,-42.68,;23.81,-44.24,;22.48,-45.01,;21.14,-44.24,;19.81,-45.02,;18.48,-44.25,;17.14,-45.02,;17.11,-46.56,;18.33,-47.49,;15.63,-47.01,;14.75,-45.74,;15.68,-44.52,;15.24,-43.04,)|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a