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Target
Bromodomain-containing protein 3
Ligand
BDBM50397667
Substrate
n/a
Meas. Tech.
ChEMBL_873615 (CHEMBL2187904)
IC50
1584.89±n/a nM
Citation
 Seal, J; Lamotte, Y; Donche, F; Bouillot, A; Mirguet, O; Gellibert, F; Nicodeme, E; Krysa, G; Kirilovsky, J; Beinke, S; McCleary, S; Rioja, I; Bamborough, P; Chung, CW; Gordon, L; Lewis, T; Walker, AL; Cutler, L; Lugo, D; Wilson, DM; Witherington, J; Lee, K; Prinjha, RK Identification of a novel series of BET family bromodomain inhibitors: binding mode and profile of I-BET151 (GSK1210151A). Bioorg Med Chem Lett 22:2968-72 (2012) [PubMed]  Article 
Target
Name:
Bromodomain-containing protein 3
Synonyms:
BRD3 | BRD3_HUMAN | Bromodomain and extra-terminal motif (BET) | Bromodomain-containing protein 3 | Bromodomain-containing protein 3 (BRD3) | KIAA0043 | RING3-like protein | RING3L
Type:
Protein
Mol. Mass.:
79571.81
Organism:
Homo sapiens (Human)
Description:
Q15059
Residue:
726
Sequence:
MSTATTVAPAGIPATPGPVNPPPPEVSNPSKPGRKTNQLQYMQNVVVKTLWKHQFAWPFYQPVDAIKLNLPDYHKIIKNPMDMGTIKKRLENNYYWSASECMQDFNTMFTNCYIYNKPTDDIVLMAQALEKIFLQKVAQMPQEEVELLPPAPKGKGRKPAAGAQSAGTQQVAAVSSVSPATPFQSVPPTVSQTPVIAATPVPTITANVTSVPVPPAAAPPPPATPIVPVVPPTPPVVKKKGVKRKADTTTPTTSAITASRSESPPPLSDPKQAKVVARRESGGRPIKPPKKDLEDGEVPQHAGKKGKLSEHLRYCDSILREMLSKKHAAYAWPFYKPVDAEALELHDYHDIIKHPMDLSTVKRKMDGREYPDAQGFAADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDEPVEAPALPAPAAPMVSKGAESSRSSEESSSDSGSSDSEEERATRLAELQEQLKAVHEQLAALSQAPVNKPKKKKEKKEKEKKKKDKEKEKEKHKVKAEEEKKAKVAPPAKQAQQKKAPAKKANSTTTAGRQLKKGGKQASASYDSEEEEEGLPMSYDEKRQLSLDINRLPGEKLGRVVHIIQSREPSLRDSNPDEIEIDFETLKPTTLRELERYVKSCLQKKQRKPFSASGKKQAAKSKEELAQEKKKELEKRLQDVSGQLSSSKKPARKEKPGSAPSGGPSRLSSSSSSESGSSSSSGSSSDSSDSE
  
Inhibitor
Name:
BDBM50397667
Synonyms:
CHEMBL2181819
Type:
Small organic molecule
Emp. Form.:
C21H18FN3O2
Mol. Mass.:
363.3849
SMILES:
COc1cc2c(Nc3ccccc3F)ccnc2cc1-c1c(C)noc1C |(65.88,-5.66,;65.88,-7.2,;67.21,-7.97,;68.56,-7.2,;69.89,-7.97,;71.23,-7.2,;71.24,-5.66,;69.91,-4.89,;68.58,-5.66,;67.25,-4.9,;67.25,-3.35,;68.58,-2.58,;69.91,-3.36,;71.25,-2.59,;72.58,-7.98,;72.58,-9.53,;71.23,-10.29,;69.89,-9.53,;68.56,-10.29,;67.21,-9.53,;65.88,-10.29,;65.72,-11.82,;66.87,-12.85,;64.22,-12.14,;63.45,-10.81,;64.47,-9.67,;64.15,-8.16,)|
Structure:
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