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Target
Glycogen synthase kinase-3 beta
Ligand
BDBM50397744
Substrate
n/a
Meas. Tech.
ChEMBL_874335 (CHEMBL2182243)
IC50
87±n/a nM
Citation
 Berg, S; Bergh, M; Hellberg, S; Högdin, K; Lo-Alfredsson, Y; Söderman, P; von Berg, S; Weigelt, T; Ormö, M; Xue, Y; Tucker, J; Neelissen, J; Jerning, E; Nilsson, Y; Bhat, R Discovery of novel potent and highly selective glycogen synthase kinase-3ß (GSK3ß) inhibitors for Alzheimer's disease: design, synthesis, and characterization of pyrazines. J Med Chem 55:9107-19 (2012) [PubMed]  Article 
Target
Name:
Glycogen synthase kinase-3 beta
Synonyms:
GSK-3 beta | GSK3B_MOUSE | Gsk3b
Type:
PROTEIN
Mol. Mass.:
46722.37
Organism:
Mus musculus
Description:
ChEMBL_660471
Residue:
420
Sequence:
MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASPPANATAASDTNAGDRGQTNNAASASASNST
  
Inhibitor
Name:
BDBM50397744
Synonyms:
CHEMBL2177163
Type:
Small organic molecule
Emp. Form.:
C21H22N6O3S
Mol. Mass.:
438.503
SMILES:
Nc1ncc(nc1C(=O)Nc1cccnc1)-c1ccc(cc1)S(=O)(=O)N1CCCCC1
Structure:
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