Reaction Details Report a problem with these data
Target
P2Y purinoceptor 1
Ligand
BDBM50398072
Substrate
n/a
Meas. Tech.
ChEMBL_873670 (CHEMBL2188786)
EC50
2.6±n/a nM
Citation
 Yelovitch, S; Barr, HM; Camden, J; Weisman, GA; Shai, E; Varon, D; Fischer, B Identification of a promising drug candidate for the treatment of type 2 diabetes based on a P2Y(1) receptor agonist. J Med Chem 55:7623-35 (2012) [PubMed]  Article 
Target
Name:
P2Y purinoceptor 1
Synonyms:
ATP receptor | P2RY1_RAT | P2Y1 | P2ry1 | Purinergic receptor | Purinergic receptor P2Y1
Type:
PROTEIN
Mol. Mass.:
42338.46
Organism:
Rattus norvegicus
Description:
ChEMBL_873671
Residue:
373
Sequence:
MTEVPWSAVPNGTDAAFLAGLGSLWGNSTIASTAAVSSSFRCALIKTGFQFYYLPAVYILVFIIGFLGNSVAIWMFVFHMKPWSGISVYMFNLALADFLYVLTLPALIFYYFNKTDWIFGDVMCKLQRFIFHVNLYGSILFLTCISAHRYSGVVYPLKSLGRLKKKNAIYVSVLVWLIVVVAISPILFYSGTGIRKNKTVTCYDSTSDEYLRSYFIYSMCTTVAMFCIPLVLILGCYGLIVRALIYKDLDNSPLRRKSIYLVIIVLTVFAVSYIPFHVMKTMNLRARLDFQTPEMCDFNDRVYATYQVTRGLASLNSCVDPILYFLAGDTFRRRLSRATRKASRRSEANLQSKSEEMTLNILSEFKQNGDTSL
  
Inhibitor
Name:
BDBM50398072
Synonyms:
CHEMBL2181943
Type:
Small organic molecule
Emp. Form.:
C11H17BN5O12P3S
Mol. Mass.:
547.078
SMILES:
[BH3-][P@@](=O)(OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)nc(SC)nc12)OP([O-])(=O)OP([O-])([O-])=O |r|
Structure:
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