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TargetHTR4
LigandBDBM50398588
Substrate/Competitorn/a
Meas. Tech.ChEMBL_873969
EC50 1.5±n/a nM
Citation Brodney, MAJohnson, DESawant-Basak, ACoffman, KJDrummond, EMHudson, ELFisher, KENoguchi, HWaizumi, NMcDowell, LLPapanikolaou, APettersen, BASchmidt, AWTseng, EStutzman-Engwall, KRubitski, DMVanase-Frawley, MAGrimwood, S Identification of multiple 5-HT4 partial agonist clinical candidates for the treatment of Alzheimer's disease. J Med Chem55:9240-54 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
HTR4
Name:Serotonin (5-HT) receptor
Synonyms:5-HT-4 | 5-HT4 | 5-HT4L | 5-HT4S | 5-hydroxytryptamine receptor 4 | Serotonin (5-HT) receptor | Serotonin 4 (5-HT4) receptor
Type:Enzyme Catalytic Domain
Mol. Mass.:46117.31
Organism:RAT
Description:5-HT4 HTR4 RAT::Q62758
Residue:406
Sequence:
MDRLDANVSSNEGFGSVEKVVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIKTNYFIV
SLAFADLLVSVLVNAFGAIELVQDIWFYGEMFCLVRTSLDVLLTTASIFHLCCISLDRYY
AICCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNIGIVDVIEKRKFNHNSN
STFCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQQIQMLQRAGATSESRP
QTADQHSTHRMRTETKAAKTLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEKVWTAFLWL
GYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYKRPPILGQTVPCSTTTINGSTHVLRD
TVECGGQWESRCHLTATSPLVAAQPVIRRPQDNDLEDSCSLKRSQS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50398588
NameBDBM50398588
Synonyms:CHEMBL2179582
TypeSmall organic molecule
Emp. Form.C23H32FN3O4
Mol. Mass.433.5163
SMILESCC1(C)C(=O)N(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c2cc(F)ccc12
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
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