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Target5-hydroxytryptamine receptor 4 (5-HT4)
LigandBDBM50398597
Substrate/Competitorn/a
Meas. Tech.ChEMBL_873995
EC50 0.80±n/a nM
Citation Brodney, MAJohnson, DESawant-Basak, ACoffman, KJDrummond, EMHudson, ELFisher, KENoguchi, HWaizumi, NMcDowell, LLPapanikolaou, APettersen, BASchmidt, AWTseng, EStutzman-Engwall, KRubitski, DMVanase-Frawley, MAGrimwood, S Identification of multiple 5-HT4 partial agonist clinical candidates for the treatment of Alzheimer's disease. J Med Chem55:9240-54 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
5-hydroxytryptamine receptor 4 (5-HT4)
Name:Serotonin (5-HT) receptor
Synonyms:5-HT-4 | 5-HT4 | 5-HT4S | 5-HT4a | 5-HT4b | 5-HT4c | 5-HT4d | 5-HT4hb | 5-hydroxytryptamine receptor 4 | HTR4 | Serotonin (5-HT) receptor | Serotonin (5-HT3) receptor | Serotonin 4 (5-HT4) receptor | Serotonin Receptor 4
Type:Enzyme
Mol. Mass.:43767.54
Organism:Homo sapiens (Human)
Description:Q13639
Residue:388
Sequence:
MDKLDANVSSEEGFGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIV
SLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYY
AICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSN
STYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRP
QSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWL
GYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLRD
AVECGGQWESQCHPPATSPLVAAQPSDT
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50398597
NameBDBM50398597
Synonyms:CHEMBL2179584
TypeSmall organic molecule
Emp. Form.C21H30N2O3
Mol. Mass.358.4745
SMILESCCCCN1CCC(COc2noc3cccc(OC4CCC4)c23)CC1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a