Reaction Details Report a problem with these data
Target
Uridine 5'-monophosphate synthase
Ligand
BDBM50398699
Substrate
n/a
Meas. Tech.
ChEMBL_874989 (CHEMBL2183865)
Ki
220000±n/a nM
Citation
Purohit, MK; Poduch, E; Wei, LW; Crandall, IE; To, T; Kain, KC; Pai, EF; Kotra, LP Novel cytidine-based orotidine-5'-monophosphate decarboxylase inhibitors with an unusual twist. J Med Chem 55:9988-97 (2012) [PubMed] Article
More Info.:
Target
Name:
Uridine 5'-monophosphate synthase
Synonyms:
Orotate phosphoribosyltransferase (HsOPRT) | Orotidine Monophosphate Decarboxylase (ODCase) | UMPS | UMPS_HUMAN
Type:
Enzyme
Mol. Mass.:
52224.99
Organism:
Homo sapiens (Human)
Description:
P11172
Residue:
480
Sequence:
MAVARAALGPLVTGLYDVQAFKFGDFVLKSGLSSPIYIDLRGIVSRPRLLSQVADILFQTAQNAGISFDTVCGVPYTALPLATVICSTNQIPMLIRRKETKDYGTKRLVEGTINPGETCLIIEDVVTSGSSVLETVEVLQKEGLKVTDAIVLLDREQGGKDKLQAHGIRLHSVCTLSKMLEILEQQKKVDAETVGRVKRFIQENVFVAANHNGSPLSIKEAPKELSFGARAELPRIHPVASKLLRLMQKKETNLCLSADVSLARELLQLADALGPSICMLKTHVDILNDFTLDVMKELITLAKCHEFLIFEDRKFADIGNTVKKQYEGGIFKIASWADLVNAHVVPGSGVVKGLQEVGLPLHRGCLLIAEMSSTGSLATGDYTRAAVRMAEEHSEFVVGFISGSRVSMKPEFLHLTPGVQLEAGGDNLGQQYNSPQEVIGKRGSDIIIVGRGIISAADRLEAAEMYRKAAWEAYLSRLGV