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Target
Kappa-type opioid receptor
Ligand
BDBM50398948
Substrate
n/a
Meas. Tech.
ChEMBL_875493 (CHEMBL2183134)
Ki
2.8±n/a nM
Citation
 Moynihan, HA; Derrick, I; Broadbear, JH; Greedy, BM; Aceto, MD; Harris, LS; Purington, LC; Thomas, MP; Woods, JH; Traynor, JR; Husbands, SM; Lewis, JW Fumaroylamino-4,5-epoxymorphinans and related opioids with irreversibleµ opioid receptor antagonist effects. J Med Chem 55:9868-74 (2012) [PubMed]  Article 
Target
Name:
Kappa-type opioid receptor
Synonyms:
Kappa Opioid Receptor | OPIATE Kappa | OPRK1 | OPRK_CAVPO | Opiate Kappa 1 | mu/kappa opioid receptor
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42744.99
Organism:
Cavia porcellus (domestic guinea pig)
Description:
P41144
Residue:
380
Sequence:
MGRRRQGPAQPASELPARNACLLPNGSAWLPGWAEPDGNGSAGPQDEQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIILGGTKVREDVDIIECSLQFPDDDYSWWDLFMKICVFVFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPIKMRMERQSTSRVRNTVQDPAYMRNVDGVNKPV
  
Inhibitor
Name:
BDBM50398948
Synonyms:
CHEMBL2179261
Type:
Small organic molecule
Emp. Form.:
C29H36N2O6
Mol. Mass.:
508.6059
SMILES:
COC(=O)\C=C\C(=O)NC[C@H]1C[C@]23CC[C@]1(OC)[C@@H]1Oc4c5c(C[C@H]2N(CC2CC2)CC[C@@]315)ccc4O |r,THB:9:10:32.18:14.13|
Structure:
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