Reaction Details Report a problem with these data
Target
Monoglyceride lipase
Ligand
BDBM50399288
Substrate
n/a
Meas. Tech.
ChEMBL_877097 (CHEMBL2186833)
IC50
248.9±n/a nM
Citation
 Alapafuja, SO; Nikas, SP; Bharathan, IT; Shukla, VG; Nasr, ML; Bowman, AL; Zvonok, N; Li, J; Shi, X; Engen, JR; Makriyannis, A Sulfonyl fluoride inhibitors of fatty acid amide hydrolase. J Med Chem 55:10074-89 (2012) [PubMed]  Article 
Target
Name:
Monoglyceride lipase
Synonyms:
HU-K5 | Lysophospholipase homolog | Lysophospholipase-like | MAGL | MGL | MGLL | MGLL_HUMAN
Type:
Hydrolase
Mol. Mass.:
33264.56
Organism:
Homo sapiens (Human)
Description:
Human recombinant MGL (Cayman Chemical, cat# 10008354).
Residue:
303
Sequence:
MPEESSPRRTPQSIPYQDLPHLVNADGQYLFCRYWKPTGTPKALIFVSHGAGEHSGRYEELARMLMGLDLLVFAHDHVGHGQSEGERMVVSDFHVFVRDVLQHVDSMQKDYPGLPVFLLGHSMGGAIAILTAAERPGHFAGMVLISPLVLANPESATTFKVLAAKVLNLVLPNLSLGPIDSSVLSRNKTEVDIYNSDPLICRAGLKVCFGIQLLNAVSRVERALPKLTVPFLLLQGSADRLCDSKGAYLLMELAKSQDKTLKIYEGAYHVLHKELPEVTNSVFHEINMWVSQRTATAGTASPP
  
Inhibitor
Name:
BDBM50399288
Synonyms:
CHEMBL2180830 | US9102622, 13.1
Type:
Small organic molecule
Emp. Form.:
C20H25FO3S
Mol. Mass.:
364.474
SMILES:
FS(=O)(=O)CCCCCCCc1ccc(OCc2ccccc2)cc1
Structure:
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