Reaction Details Report a problem with these data
Target
Complement factor D
Ligand
BDBM50400276
Substrate
n/a
Meas. Tech.
ChEMBL_872411 (CHEMBL2188699)
IC50
24750±n/a nM
Citation
 Abdel-Magid, AF Factor D Inhibitors for the Treatment of AMD: Patent Highlight. ACS Med Chem Lett 3:781-782 (2012) [PubMed]  Article 
Target
Name:
Complement factor D
Synonyms:
Adipsin | C3 convertase activator | CFAD_HUMAN | CFD | DF | PFD | Properdin factor D
Type:
Protein
Mol. Mass.:
27039.19
Organism:
Homo sapiens (Human)
Description:
P00746
Residue:
253
Sequence:
MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA
  
Inhibitor
Name:
BDBM50400276
Synonyms:
CHEMBL2181048 | US9085555, 82
Type:
Small organic molecule
Emp. Form.:
C23H26N6O4
Mol. Mass.:
450.4903
SMILES:
N[C@H]1C[C@H](N(C1)C(=O)Nc1cn(C(N)=O)c2ccccc12)C(=O)NCC(O)c1ccccc1 |r|
Structure:
Search PDB for entries with ligand similarity: