Reaction Details Report a problem with these data
Target
NAD-dependent protein deacylase sirtuin-5, mitochondrial
Ligand
BDBM27507
Substrate
n/a
Meas. Tech.
ChEMBL_880330 (CHEMBL2209185)
IC50
46600±n/a nM
Citation
 Maurer, B; Rumpf, T; Scharfe, M; Stolfa, DA; Schmitt, ML; He, W; Verdin, E; Sippl, W; Jung, M Inhibitors of the NAD(+)-Dependent Protein Desuccinylase and Demalonylase Sirt5. ACS Med Chem Lett 3:1050-1053 (2012) [PubMed]  Article 
Target
Name:
NAD-dependent protein deacylase sirtuin-5, mitochondrial
Synonyms:
NAD-dependent protein deacetylase sirtuin-5 (SIRT5) | NAD-dependent protein deacylase sirtuin-5, mitochondrial | Regulatory protein SIR2 homolog 5 | SIR2-like protein 5 | SIR2L5 | SIR5_HUMAN | SIRT5
Type:
Protein
Mol. Mass.:
33892.62
Organism:
Homo sapiens (Human)
Description:
Q9NXA8
Residue:
310
Sequence:
MRPLQIVPSRLISQLYCGLKPPASTRNQICLKMARPSSSMADFRKFFAKAKHIVIISGAGVSAESGVPTFRGAGGYWRKWQAQDLATPLAFAHNPSRVWEFYHYRREVMGSKEPNAGHRAIAECETRLGKQGRRVVVITQNIDELHRKAGTKNLLEIHGSLFKTRCTSCGVVAENYKSPICPALSGKGAPEPGTQDASIPVEKLPRCEEAGCGGLLRPHVVWFGENLDPAILEEVDRELAHCDLCLVVGTSSVVYPAAMFAPQVAARGVPVAEFNTETTPATNRFRFHFQGPCGTTLPEALACHENETVS
  
Inhibitor
Name:
BDBM27507
Synonyms:
3-Pyridinecarboxamide | CHEMBL1140 | NAM | niacinamide | nicotinamide | pyridine-3-carboxamide
Type:
n/a
Emp. Form.:
C6H6N2O
Mol. Mass.:
122.1246
SMILES:
NC(=O)c1cccnc1
Structure:
Search PDB for entries with ligand similarity: