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Target
Casein kinase I isoform gamma-2
Ligand
BDBM50400753
Substrate
n/a
Meas. Tech.
ChEMBL_880536 (CHEMBL2211471)
IC50
4±n/a nM
Citation
 Huang, H; Acquaviva, L; Berry, V; Bregman, H; Chakka, N; DiMauro, EF; Dovey, J; Epstein, O; Grubinska, B; Goldstein, J; Gunaydin, H; Hua, Z; Huang, X; Huang, L; Human, J; Long, A; Newcomb, J; Patel, VF; Saffran, D; Serafino, R; Schneider, S; Strathdee, C; Tang, J; Turci, S; White, R; Yu, V; Zhao, H; Wilson, C; Martin, MW Structure-Based Design of Potent and Selective CK1¿ Inhibitors. ACS Med Chem Lett 3:1059-1064 (2012) [PubMed]  Article 
Target
Name:
Casein kinase I isoform gamma-2
Synonyms:
CK1G2 | CSNK1G2 | Casein kinase I | Casein kinase I gamma 2 | KC1G2_HUMAN
Type:
PROTEIN
Mol. Mass.:
47475.36
Organism:
Homo sapiens (Human)
Description:
ChEMBL_774313
Residue:
415
Sequence:
MDFDKKGGKGETEEGRRMSKAGGGRSSHGIRSSGTSSGVLMVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQLSATEGVPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLITRMEYVHTKSLIYRDVKPENFLVGRPGTKRQHAIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENFPEEMATYLRYVRRLDFFEKPDYDYLRKLFTDLFDRSGFVFDYEYDWAGKPLPTPIGTVHTDLPSQPQLRDKTQPHSKNQALNSTNGELNADDPTAGHSNAPITAPAEVEVADETKCCCFFKRRKRKSLQRHK
  
Inhibitor
Name:
BDBM50400753
Synonyms:
CHEMBL2203565
Type:
Small organic molecule
Emp. Form.:
C21H19F2N3O3
Mol. Mass.:
399.3907
SMILES:
COc1cnc(COc2cc(F)c(F)cc2C)cc1-c1cc2c(CCNC2=O)[nH]1
Structure:
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