Target
DNA (cytosine-5)-methyltransferase 3B
Ligand
BDBM50400781
Substrate
n/a
Meas. Tech.
ChEMBL_879146 (CHEMBL2209117)
IC50
>100000±n/a nM
Citation
 Verma, SKTian, XLaFrance, LVDuquenne, CSuarez, DPNewlander, KARomeril, SPBurgess, JLGrant, SWBrackley, JAGraves, APScherzer, DAShu, AThompson, COtt, HMAller, GSMachutta, CADiaz, EJiang, YJohnson, NWKnight, SDKruger, RGMcCabe, MTDhanak, DTummino, PJCreasy, CLMiller, WH Identification of Potent, Selective, Cell-Active Inhibitors of the Histone Lysine Methyltransferase EZH2. ACS Med Chem Lett 3:1091-1096 (2012) [PubMed]  Article 
Target
Name:
DNA (cytosine-5)-methyltransferase 3B
Synonyms:
DNA MTase MmuIIIB | DNA methyltransferase MmuIIIB | DNM3B_MOUSE | Dnmt3b
Type:
PROTEIN
Mol. Mass.:
97245.99
Organism:
Mus musculus
Description:
ChEMBL_879146
Residue:
859
Sequence:
MKGDSRHLNEEEGASGYEECIIVNGNFSDQSSDTKDAPSPPVLEAICTEPVCTPETRGRRSSSRLSKREVSSLLNYTQDMTGDGDRDDEVDDGNGSDILMPKLTRETKDTRTRSESPAVRTRHSNGTSSLERQRASPRITRGRQGRHHVQEYPVEFPATRSRRRRASSSASTPWSSPASVDFMEEVTPKSVSTPSVDLSQDGDQEGMDTTQVDAESRDGDSTEYQDDKEFGIGDLVWGKIKGFSWWPAMVVSWKATSKRQAMPGMRWVQWFGDGKFSEISADKLVALGLFSQHFNLATFNKLVSYRKAMYHTLEKARVRAGKTFSSSPGESLEDQLKPMLEWAHGGFKPTGIEGLKPNKKQPVVNKSKVRRSDSRNLEPRRRENKSRRRTTNDSAASESPPPKRLKTNSYGGKDRGEDEESRERMASEVTNNKGNLEDRCLSCGKKNPVSFHPLFEGGLCQSCRDRFLELFYMYDEDGYQSYCTVCCEGRELLLCSNTSCCRCFCVECLEVLVGAGTAEDAKLQEPWSCYMCLPQRCHGVLRRRKDWNMRLQDFFTTDPDLEEFEPPKLYPAIPAAKRRPIRVLSLFDGIATGYLVLKELGIKVEKYIASEVCAESIAVGTVKHEGQIKYVNDVRKITKKNIEEWGPFDLVIGGSPCNDLSNVNPARKGLYEGTGRLFFEFYHLLNYTRPKEGDNRPFFWMFENVVAMKVNDKKDISRFLACNPVMIDAIKVSAAHRARYFWGNLPGMNRPVMASKNDKLELQDCLEFSRTAKLKKVQTITTKSNSIRQGKNQLFPVVMNGKDDVLWCTELERIFGFPAHYTDVSNMGRGARQKLLGRSWSVPVIRHLFAPLKDYFACE
  
Inhibitor
Name:
BDBM50400781
Synonyms:
CHEMBL2204997
Type:
Small organic molecule
Emp. Form.:
C31H39N7O2
Mol. Mass.:
541.6871
SMILES:
CCCc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(cc2n(ncc12)C(C)C)-c1ccc(nc1)N1CCN(C)CC1
Structure:
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