Reaction Details Report a problem with these data
Target
Histamine H3 receptor
Ligand
BDBM50278350
Substrate
n/a
Meas. Tech.
ChEMBL_882946 (CHEMBL2209374)
Kd
0.34±n/a nM
Citation
 Selivanova, SV; Honer, M; Combe, F; Isensee, K; Stark, H; Krämer, SD; Schubiger, PA; Ametamey, SM Radiofluorinated histamine H3 receptor antagonist as a potential probe for in vivo PET imaging: radiosynthesis and pharmacological evaluation. Bioorg Med Chem 20:2889-96 (2012) [PubMed]  Article 
Target
Name:
Histamine H3 receptor
Synonyms:
HH3R | HRH3_RAT | Hrh3
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
48607.98
Organism:
Rattus norvegicus (rat)
Description:
n/a
Residue:
445
Sequence:
MERAPPDGLMNASGTLAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCASSVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMALVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGREAGPEPPPDAQPSPPPAPPSCWGCWPKGHGEAMPLHRYGVGEAGPGVEAGEAALGGGSGGGAAASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSLAIIVSIFGLCWAPYTLLMIIRAACHGRCIPDYWYETSFWLLWANSAVNPVLYPLCHYSFRRAFTKLLCPQKLKVQPHGSLEQCWK
  
Inhibitor
Name:
BDBM50278350
Synonyms:
4-fluoro-1-(4-(3-(piperidin-1-yl)propoxy)benzyl)piperidine | CHEMBL2203701 | CHEMBL513193
Type:
Small organic molecule
Emp. Form.:
C20H31FN2O
Mol. Mass.:
334.4713
SMILES:
FC1CCN(Cc2ccc(OCCCN3CCCCC3)cc2)CC1
Structure:
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