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Target
Urokinase plasminogen activator surface receptor
Ligand
BDBM50401179
Substrate
n/a
Meas. Tech.
ChEMBL_881708 (CHEMBL2209754)
IC50
>100000±n/a nM
Citation
 Wang, F; Eric Knabe, W; Li, L; Jo, I; Mani, T; Roehm, H; Oh, K; Li, J; Khanna, M; Meroueh, SO Design, synthesis, biochemical studies, cellular characterization, and structure-based computational studies of small molecules targeting the urokinase receptor. Bioorg Med Chem 20:4760-73 (2012) [PubMed]  Article 
Target
Name:
Urokinase plasminogen activator surface receptor
Synonyms:
CD_antigen=CD87 | MO3 | Monocyte activation antigen Mo3 | PLAUR | U-PAR | UPAR | UPAR_HUMAN | Urokinase plasminogen activator surface receptor | Urokinase receptor (uPAR) | Urokinase-type plasminogen activator/surface receptor
Type:
Receptor
Mol. Mass.:
36979.14
Organism:
Homo sapiens (Human)
Description:
Q03405
Residue:
335
Sequence:
MGHPPLLPLLLLLHTCVPASWGLRCMQCKTNGDCRVEECALGQDLCRTTIVRLWEEGEELELVEKSCTHSEKTNRTLSYRTGLKITSLTEVVCGLDLCNQGNSGRAVTYSRSRYLECISCGSSDMSCERGRHQSLQCRSPEEQCLDVVTHWIQEGEEGRPKDDRHLRGCGYLPGCPGSNGFHNNDTFHFLKCCNTTKCNEGPILELENLPQNGRQCYSCKGNSTHGCSSEETFLIDCRGPMNQCLVATGTHEPKNQSYMVRGCATASMCQHAHLGDAFSMNHIDVSCCTKSGCNHPDLDVQYRSGAAPQPGPAHLSLTITLLMTARLWGGTLLWT
  
Inhibitor
Name:
BDBM50401179
Synonyms:
CHEMBL2206355
Type:
Small organic molecule
Emp. Form.:
C28H25N3O4
Mol. Mass.:
467.5158
SMILES:
COC(=O)c1cccc(Nc2cc(N3CCCCCC3)c3noc4-c5ccccc5C(=O)c2c34)c1
Structure:
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