Reaction Details
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Peptidyl-glycine alpha-amidating monooxygenase
Ligand
BDBM50401758
Substrate
n/a
Meas. Tech.
ChEMBL_885021 (CHEMBL2211745)
IC50
120000±n/a nM
Citation
Morris, KM; Cao, F; Onagi, H; Altamore, TM; Gamble, AB; Easton, CJ Prohormone-substrate peptide sequence recognition by peptidylglycinea-amidating monooxygenase and its reflection in increased glycolate inhibitor potency. Bioorg Med Chem Lett 22:7015-8 (2012) [PubMed] Article More Info.:
Target
Name:
Peptidyl-glycine alpha-amidating monooxygenase
Synonyms:
AMD_HUMAN | PAL | PAM | PHM | Peptidyl-alpha-hydroxyglycine alpha-amidating lyase | Peptidylamidoglycolate lyase | Peptidylglycine alpha-hydroxylating monooxygenase
Type:
PROTEIN
Mol. Mass.:
108328.29
Organism:
Homo sapiens (Human)
Description:
ChEMBL_885021
Residue:
973
Sequence:
MAGRVPSLLVLLVFPSSCLAFRSPLSVFKRFKETTRPFSNECLGTTRPVVPIDSSDFALDIRMPGVTPKQSDTYFCMSMRIPVDEEAFVIDFKPRASMDTVHHMLLFGCNMPSSTGSYWFCDEGTCTDKANILYAWARNAPPTRLPKGVGFRVGGETGSKYFVLQVHYGDISAFRDNNKDCSGVSLHLTRLPQPLIAGMYLMMSVDTVIPAGEKVVNSDISCHYKNYPMHVFAYRVHTHHLGKVVSGYRVRNGQWTLIGRQSPQLPQAFYPVGHPVDVSFGDLLAARCVFTGEGRTEATHIGGTSSDEMCNLYIMYYMEAKHAVSFMTCTQNVAPDMFRTIPPEANIPIPVKSDMVMMHEHHKETEYKDKIPLLQQPKREEEEVLDQGDFYSLLSKLLGEREDVVHVHKYNPTEKAESESDLVAEIANVVQKKDLGRSDAREGAEHERGNAILVRDRIHKFHRLVSTLRPPESRVFSLQQPPPGEGTWEPEHTGDFHMEEALDWPGVYLLPGQVSGVALDPKNNLVIFHRGDHVWDGNSFDSKFVYQQIGLGPIEEDTILVIDPNNAAVLQSSGKNLFYLPHGLSIDKDGNYWVTDVALHQVFKLDPNNKEGPVLILGRSMQPGSDQNHFCQPTDVAVDPGTGAIYVSDGYCNSRIVQFSPSGKFITQWGEESSGSSPLPGQFTVPHSLALVPLLGQLCVADRENGRIQCFKTDTKEFVREIKHSSFGRNVFAISYIPGLLFAVNGKPHFGDQEPVQGFVMNFSNGEIIDIFKPVRKHFDMPHDIVASEDGTVYIGDAHTNTVWKFTLTEKLEHRSVKKAGIEVQEIKEAEAVVETKMENKPTSSELQKMQEKQKLIKEPGSGVPVVLITTLLVIPVVVLLAIAIFIRWKKSRAFGDSEHKLETSSGRVLGRFRGKGSGGLNLGNFFASRKGYSRKGFDRLSTEGSDQEKEDDGSESEEEYSAPLPALAPSSS
Inhibitor
Name:
BDBM50401758
Synonyms:
CHEMBL2207141
Type:
Small organic molecule
Emp. Form.:
C12H20N2O6
Mol. Mass.:
288.297
SMILES:
CC(C)C[C@H](NC(C)=O)C(=O)NCC(=O)OCC(O)=O |r|
Structure:
