Target
Serine/threonine-protein kinase TBK1
Ligand
BDBM50401926
Substrate
n/a
Meas. Tech.
ChEMBL_886437 (CHEMBL2213809)
IC50
>1000±n/a nM
Citation
 McIver, EGBryans, JBirchall, KChugh, JDrake, TLewis, SJOsborne, JSmiljanic-Hurley, ETsang, WKamal, ALevy, ANewman, MTaylor, DArthur, JSClark, KCohen, P Synthesis and structure-activity relationships of a novel series of pyrimidines as potent inhibitors of TBK1/IKKe kinases. Bioorg Med Chem Lett 22:7169-73 (2012) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase TBK1
Synonyms:
T2K | TANK-binding kinase 1 | TBK1_MOUSE | Tbk1
Type:
PROTEIN
Mol. Mass.:
83429.25
Organism:
Mus musculus
Description:
ChEMBL_886437
Residue:
729
Sequence:
MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLYAVKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSVGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGAISGVQKAENGPIDWSGDMPLSCSLSQGLQALLTPVLANILEADQEKCWGFDQFFAETSDVLHRMVIHVFSLQHMTAHKIYIHSYNTAAVFHELVYKQTKIVSSNQELIYEGRRLVLELGRLAQHFPKTTEENPIFVTSREQLNTVGLRYEKISLPKIHPRYDLDGDASMAKAVTGVVCYACRTASTLLLYQELMRKGVRWLVELVKDDYNETVHKKTEVVITLDFCIRNIEKTVKVYEKLMKVNLEAAELGEISDIHTKLLRLSSSQGTIESSLQDISSRLSPGGLLADTWAHQEGTHPRDRNVEKLQVLLNCITEIYYQFKKDKAERRLAYNEEQIHKFDKQKLYYHATKAMSHFSEECVRKYEAFKDKSEEWMRKMLHLRKQLLSLTNQCFDIEEEVSKYQDYTNELQETLPQKMLAASGGVKHAMAPIYPSSNTLVEMTLGMKKLKEEMEGVVKELAENNHILERFGSLTMDGGLRNVDCL
  
Inhibitor
Name:
BDBM50401926
Synonyms:
CHEMBL2207200
Type:
Small organic molecule
Emp. Form.:
C20H26N6O
Mol. Mass.:
366.46
SMILES:
O=C(NCCCNc1nc(Nc2cccnc2)ncc1C1CC1)C1CCC1
Structure:
Search PDB for entries with ligand similarity: