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Target
Lysosomal alpha-glucosidase
Ligand
BDBM50401972
Substrate
n/a
Meas. Tech.
ChEMBL_886575 (CHEMBL2215735)
IC50
19700±n/a nM
Citation
 Patil, VS; Nandre, KP; Ghosh, S; Rao, VJ; Chopade, BA; Bhosale, SV; Bhosale, SV Synthesis and glycosidase inhibitory activity of novel (2-phenyl-4H-benzopyrimedo[2,1-b]-thiazol-4-yliden)acetonitrile derivatives. Bioorg Med Chem Lett 22:7011-4 (2012) [PubMed]  Article 
Target
Name:
Lysosomal alpha-glucosidase
Synonyms:
α-Glucosidase | Acid maltase | Gaa | LYAG_MOUSE | Lysosomal alpha-glucosidase | alpha-glucosidase (Gaa)
Type:
Enzyme
Mol. Mass.:
106235.32
Organism:
Mus musculus (Mouse)
Description:
P70699
Residue:
953
Sequence:
MNIRKPLCSNSVVGACTLISLTTAVILGHLMLRELMLLPQDLHESSSGLWKTYRPHHQEGYKPGPLHIQEQTEQPKEAPTQCDVPPSSRFDCAPDKGISQEQCEARGCCYVPAGQVLKEPQIGQPWCFFPPSYPSYRLENLSSTESGYTATLTRTSPTFFPKDVLTLQLEVLMETDSRLHFKIKDPASKRYEVPLETPRVLSQAPSPLYSVEFSEEPFGVIVRRKLGGRVLLNTTVAPLFFADQFLQLSTSLPSQHITGLGEHLSPLMLSTDWARITLWNRDTPPSQGTNLYGSHPFYLALEDGGLAHGVFLLNSNAMDVILQPSPALTWRSTGGILDVYVFLGPEPKSVVQQYLDVVGYPFMPPYWGLGFHLCRWGYSSTAIVRQVVENMTRTHFPLDVQWNDLDYMDARRDFTFNQDSFADFPDMVRELHQDGRRYMMIVDPAISSAGPAGSYRPYDEGLRRGVFITNETGQPLIGKVWPGTTAFPDFTNPETLDWWQDMVSEFHAQVPFDGMWLDMNEPSNFVRGSQQGCPNNELENPPYVPGVVGGILQAATICASSHQFLSTHYNLHNLYGLTEAIASSRALVKTRGTRPFVISRSTFSGHGRYAGHWTGDVRSSWEHLAYSVPDILQFNLLGVPLVGADICGFIGDTSEELCVRWTQLGAFYPFMRNHNDLNSVPQEPYRFSETAQQAMRKAFALRYALLPYLYTLFHRAHVRGDTVARPLFLEFPEDPSTWSVDRQLLWGPALLITPVLEPGKTEVTGYFPKGTWYNMQMVSVDSLGTLPSPSSASSFRSAVQSKGQWLTLEAPLDTINVHLREGYIIPLQGPSLTTTESRKQPMALAVALTASGEADGELFWDDGESLAVLERGAYTLVTFSAKNNTIVNKLVRVTKEGAELQLREVTVLGVATAPTQVLSNGIPVSNFTYSPDNKSLAIPVSLLMGELFQISWS
  
Inhibitor
Name:
BDBM50401972
Synonyms:
CHEMBL2207954
Type:
Small organic molecule
Emp. Form.:
C19H12ClN3OS
Mol. Mass.:
365.836
SMILES:
COc1ccc2N3C(Sc2c1)=NC(=C\C3=C/C#N)c1ccc(Cl)cc1 |c:12,14|
Structure:
Search PDB for entries with ligand similarity: