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Target
Indoleamine 2,3-dioxygenase 1
Ligand
BDBM50336640
Substrate
n/a
Meas. Tech.
ChEMBL_885589 (CHEMBL2210858)
IC50
46000±n/a nM
Citation
 Bakmiwewa, SM; Fatokun, AA; Tran, A; Payne, RJ; Hunt, NH; Ball, HJ Identification of selective inhibitors of indoleamine 2,3-dioxygenase 2. Bioorg Med Chem Lett 22:7641-6 (2012) [PubMed]  Article 
Target
Name:
Indoleamine 2,3-dioxygenase 1
Synonyms:
I23O1_MOUSE | IDO-1 | Ido | Ido1 | Indo | Indoleamine-pyrrole 2,3-dioxygenase
Type:
PROTEIN
Mol. Mass.:
45639.39
Organism:
Mus musculus
Description:
ChEMBL_1452149
Residue:
407
Sequence:
MALSKISPTEGSRRILEDHHIDEDVGFALPHPLVELPDAYSPWVLVARNLPVLIENGQLREEVEKLPTLSTDGLRGHRLQRLAHLALGYITMAYVWNRGDDDVRKVLPRNIAVPYCELSEKLGLPPILSYADCVLANWKKKDPNGPMTYENMDILFSFPGGDCDKGFFLVSLLVEIAASPAIKAIPTVSSAVERQDLKALEKALHDIATSLEKAKEIFKRMRDFVDPDTFFHVLRIYLSGWKCSSKLPEGLLYEGVWDTPKMFSGGSAGQSSIFQSLDVLLGIKHEAGKESPAEFLQEMREYMPPAHRNFLFFLESAPPVREFVISRHNEDLTKAYNECVNGLVSVRKFHLAIVDTYIMKPSKKKPTDGDKSEEPSNVESRGTGGTNPMTFLRSVKDTTEKALLSWP
  
Inhibitor
Name:
BDBM50336640
Synonyms:
(nifedipine) 2,6-Dimethyl-4-(2-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid dimethyl ester | 2,6-Dimethyl-4-(2-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid dimethyl ester | Adalat | Adalat CC | Afeditab cr | BAY-A-1040 | NIFEDIPINE | Nefidipine | Procardia | Procardia XL | dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
Type:
Small organic molecule
Emp. Form.:
C17H18N2O6
Mol. Mass.:
346.3346
SMILES:
COC(=O)C1C(C(C(=O)OC)=C(C)N=C1C)c1ccccc1[N+]([O-])=O |c:13,t:10|
Structure:
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