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TargetCandidapepsin-2
LigandBDBM50402348
Substrate/Competitorn/a
Meas. Tech.ChEMBL_885953
Ki 12±n/a nM
Citation Calugi, CTrabocchi, ADe Bernardis, FArancia, SNavarra, PCauda, RCassone, AGuarna, A Bicyclic peptidomimetics targeting secreted aspartic protease 2 (SAP2) from Candida albicans reveal a constrained inhibitory chemotype. Bioorg Med Chem20:7206-13 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Candidapepsin-2
Name:Candidapepsin-2
Synonyms:ACP 2 | Aspartate protease 2 | PRA11 | PRA2 | SAP2 | Secreted aspartic protease 2
Type:PROTEIN
Mol. Mass.:42313.90
Organism:Candida albicans
Description:ChEMBL_885955
Residue:398
Sequence:
MFLKNIFIALAIALLVDATPTTTKRSAGFVALDFSVVKTPKAFPVTNGQEGKTSKRQAVP
VTLHNEQVTYAADITVGSNNQKLNVIVDTGSSDLWVPDVNVDCQVTYSDQTADFCKQKGT
YDPSGSSASQDLNTPFKIGYGDGSSSQGTLYKDTVGFGGVSIKNQVLADVDSTSIDQGIL
GVGYKTNEAGGSYDNVPVTLKKQGVIAKNAYSLYLNSPDAATGQIIFGGVDNAKYSGSLI
ALPVTSDRELRISLGSVEVSGKTINTDNVDVLLDSGTTITYLQQDLADQIIKAFNGKLTQ
DSNGNSFYEVDCNLSGDVVFNFSKNAKISVPASEFAASLQGDDGQPYDKCQLLFDVNDAN
ILGDNFLRSAYIVYDLDDNEISLAQVKYTSASSISALT
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50402348
NameBDBM50402348
Synonyms:CHEMBL2206678
TypeSmall organic molecule
Emp. Form.C42H70N6O5
Mol. Mass.739.0424
SMILESCCCCNC(=O)[C@H](C[C@H](O)[C@H](CC1CCCCC1)NC(=O)[C@H](CCCC)N1CCN([C@H](Cc2ccccc2)C1=O)C(=O)N1CCN(C)CC1)C(C)C |r|
Structure
n/a